ERN1 anticorps (N-Term)

N° du produit ABIN1887904

Détail du produit anti-ERN1 anticorps

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide from near the amino terminus of human IRE1p.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur ERN1

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Autre désignation: IRE1p (ERN1 Produits)

Synonymes: anticorps IRE1, anticorps IRE1P, anticorps IRE1a, anticorps hIRE1p, anticorps 9030414B18Rik, anticorps AI225830, anticorps C85377, anticorps Ire1a, anticorps Ire1alpha, anticorps Ire1p, anticorps RGD1559716, anticorps Ern1, anticorps Ire1, anticorps Ire1b, anticorps sb:eu1005, anticorps zgc:109932, anticorps endoplasmic reticulum to nucleus signaling 1, anticorps endoplasmic reticulum to nucleus signaling 2, anticorps endoplasmic reticulum (ER) to nucleus signalling 1, anticorps serine/threonine-protein kinase/endoribonuclease IRE1, anticorps endoplasmic reticulum (ER) to nucleus signalling 2, anticorps ERN1, anticorps ERN2, anticorps Ern1, anticorps LOC524719, anticorps Ern2, anticorps ern1

Sujet: Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94.These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress causes their dissociation.This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus.IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation.Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: Endoplasmic reticulum-to-nucleus signaling 1, ERN1

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response