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p53 anticorps (AA 181-190)

TP53 Reactivité: Humain WB, IHC, IHC (p), IP, IHC (fro) Hôte: Souris Monoclonal DO-11 unconjugated

N° du produit ABIN198283

Fiche de données

Antigène Voir toutes p53 (TP53) Anticorps

p53 (TP53) (Tumor Protein P53 (TP53))
Épitope
51

41

40

39

32

30

28

25

24

24

23

20

20

20

18

18

16

16

14

13

10

9

9

9

9

9

8

7

7

7

7

7

6

6

6

6

5

5

5

4

4

4

3

3

3

3

3

3

3

3
AA 181-190
Reactivité
899

272

223

113

48

35

33

19

10

8

8

6

4

4

3

3

2

2

2

2

1

1

1

1

1
Humain
Hôte
676

238

6

2

1

1
Souris
Anticorps secondaires appropriés
Clonalité
611

312

1
Monoclonal
Conjugué
516

49

40

26

25

25

24

24

23

22

22

13

13

13

13

13

13

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
Cet anticorp p53 est non-conjugé
Application
723

336

257

216

210

150

128

124

119

65

61

35

20

17

13

12

12

10

9

8

6

4

3

3

2

2

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité

Recognizes the human Cellular tumor antigen p53, also known as p53 tumor suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kD cytoplasmic/ nuclear protein up-regulated in response to DNA damage and is found in a wide variety of transformed cells. DO-11 binds to an epitope within the central region of p53 between amino acids defining a cryptic epitope exposed in unfolded/ denatured p53. Nine isoforms of human p53 are produced by alternative splicing and promoter usage, the epitope recognized by clone DO-11 is present in all isoforms. Recognizes mutant forms of p53 and has been used successfully for detection of p53 by western blotting.

Purification

Purified IgG

Immunogène

Recombinant human p53 ( AA 181-190 ).

Type of Immunogen: Recombinant protein

Clone

DO-11

Isotype

IgG1

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anti-Tumor Protein P53 (TP53) (pSer20) antibody
TP53 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated

Indications d'application

Approved: IHC, IHC-Fr, IHC-P (1:1000), IP, WB (1:1000)

Usage: Immunohistology: This product does require antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer  pH 6.0 is recommended for this purpose.

Commentaires

Target Species of Antibody: Human

Restrictions

For Research Use only
Format

Liquid

Concentration

Lot specific

Buffer

PBS,  pH 7.4, 0.09 % sodium azide.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C,-20 °C

Stockage commentaire

4°C or -20°C, Avoid freeze-thaw cycles.
Antigène

p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation

TP53 / p53 (TP53 Produits)

Synonymes

anticorps BCC7, anticorps LFS1, anticorps P53, anticorps TRP53, anticorps p53, anticorps Trp53, anticorps brp53, anticorps drp53, anticorps etID22686.5, anticorps fb40d06, anticorps wu:fb40d06, anticorps zgc:111919, anticorps Tp53, anticorps bbl, anticorps bfy, anticorps bhy, anticorps p44, anticorps tp53, anticorps Xp53, anticorps TP53, anticorps tumor protein p53, anticorps cellular tumor antigen p53, anticorps transformation related protein 53, anticorps tumor protein p53 L homeolog, anticorps TP53, anticorps CpipJ_CPIJ002758, anticorps Tp53, anticorps tp53, anticorps Trp53, anticorps tp53.L

Sujet

Name/Gene ID: TP53
Family: P53

Synonyms: TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1

ID gène

7157

UniProt

P04637

Pathways

Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg