HIF1A anticorps (AA 579-826)

N° du produit ABIN1992685

Détail du produit anti-HIF1A anticorps

Antigène: HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Épitope: AA 579-826

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIF1A est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Hypoxia-inducible factor 1-alpha protein (579-826AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HIF1A

Antigène: HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))

Autre désignation: HIF1A (HIF1A Produits)

Synonymes: anticorps hif1a, anticorps AA959795, anticorps HIF1alpha, anticorps MOP1, anticorps bHLHe78, anticorps HIF-1A, anticorps HIF-1alpha, anticorps HIF1, anticorps HIF1-ALPHA, anticorps PASD8, anticorps HIF1-alpha, anticorps hif-1a, anticorps hypoxia inducible factor 1 alpha, anticorps hypoxia inducible factor 1, alpha subunit, anticorps hypoxia inducible factor 1 alpha subunit, anticorps HIF (Hypoxia Inducible Factor) homologa, anticorps hif-1a, anticorps Hif1a, anticorps HIF1A, anticorps hif1a, anticorps hif-1

Sujet:

Background: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5\\\'-[AG]CGTG-3\\\' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

Aliases: ARNT interacting protein antibody, ARNT-interacting protein antibody, Basic helix loop helix PAS protein MOP1 antibody, Basic-helix-loop-helix-PAS protein MOP1 antibody, bHLHe78 antibody, Class E basic helix-loop-helix protein 78 antibody, HIF 1A antibody, HIF 1alpha antibody, HIF-1-alpha antibody, HIF-1alpha antibody, HIF-alpha antibody, HIF1 A antibody, HIF1 Alpha antibody, HIF1 antibody, HIF1-alpha antibody, HIF1A antibody, HIF1A_HUMAN antibody, hifla antibody, Hypoxia inducible factor 1 alpha antibody, Hypoxia inducible factor 1 alpha isoform I.3 antibody, Hypoxia inducible factor 1 alpha subunit antibody, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor antibody, Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor) antibody, Hypoxia inducible factor1alpha antibody, Hypoxia-inducible factor 1-alpha antibody, Member of PAS protein 1 antibody, Member of PAS superfamily 1 antibody, Member of the PAS Superfamily 1 antibody, MOP 1 antibody, MOP1 antibody, PAS domain-containing protein 8 antibody, PASD 8 antibody, PASD8 antibody

UniProt: Q16665

Pathways: Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, L'effet Warburg