PDGFB anticorps

N° du produit ABIN2432206

Détail du produit anti-PDGFB anticorps

Antigène: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDGFB est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Purification: Affinity purification

Immunogène: Synthetic peptide of human PDGFB

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PDGFB

Antigène: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Autre désignation: PDGFB (PDGFB Produits)

Synonymes: anticorps PDGF-2, anticorps PDGF2, anticorps SIS, anticorps SSV, anticorps c-sis, anticorps pdgf2, anticorps sis, anticorps si:ch211-79m20.1, anticorps si:dkey-261d11.1, anticorps PDGF-B, anticorps Sis, anticorps platelet derived growth factor subunit B, anticorps platelet-derived growth factor beta polypeptide, anticorps platelet derived growth factor subunit B S homeolog, anticorps platelet-derived growth factor beta polypeptide a, anticorps platelet derived growth factor, B polypeptide, anticorps PDGFB, anticorps pdgfb.S, anticorps pdgfba, anticorps Pdgfb

Sujet: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

NCBI Accession: NP_002599

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling