STAT5B anticorps
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- Antigène Voir toutes STAT5B Anticorps
- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp STAT5B est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by peptide affinity chromatography method.
- Immunogène
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human STAT5B.
- Top Product
- Discover our top product STAT5B Anticorps primaire
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- Indications d'application
- STAT5B antibody can be used for detection of STAT5B by ELISA at 1:1562500. STAT5B antibody can be used for detection of STAT5B by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Conseil sur la manipulation
- As with any antibody avoid repeat freeze-thaw cycles.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store STAT5B antibody at -20 °C.
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- Antigène
- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
- Autre désignation
- STAT5B (STAT5B Produits)
- Synonymes
- anticorps STAT5, anticorps stat5, anticorps STAT5A, anticorps STAT5B, anticorps signal transducer and activator of transcription 5B, anticorps signal transducer and activator of transcription 5B S homeolog, anticorps Signal transducer and activator of transcription 5B, anticorps STAT5B, anticorps Stat5b, anticorps stat5b.S, anticorps LOC490969, anticorps sta5b, anticorps LOC100566752, anticorps LOC100052954
- Sujet
- The protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- Poids moléculaire
- 90 kDa
- ID gène
- 6777
- NCBI Accession
- NP_036580
- UniProt
- P51692
- Pathways
- Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
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