NCOR2 anticorps

N° du produit ABIN2460475

Détail du produit anti-NCOR2 anticorps

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOR2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NCOR2.

Information d'application

Indications d'application: NCOR2 antibody can be used for detection of NCOR2 by ELISA at 1:12500. NCOR2 antibody can be used for detection of NCOR2 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store NCOR2 antibody at -20 °C.

Détails sur NCOR2

Antigène: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Autre désignation: NCOR2 (NCOR2 Produits)

Synonymes: anticorps CTG26, anticorps N-CoR2, anticorps SMAP270, anticorps SMRT, anticorps SMRTE, anticorps SMRTE-tau, anticorps TNRC14, anticorps TRAC, anticorps TRAC-1, anticorps TRAC1, anticorps N-CoR, anticorps SMRTe, anticorps NCOR2, anticorps gb:be017685, anticorps si:bz71m17.2, anticorps smrt, anticorps ctg26, anticorps smrte, anticorps trac1, anticorps tnrc14, anticorps trac-1, anticorps smrte-tau, anticorps nuclear receptor corepressor 2, anticorps nuclear receptor co-repressor 2, anticorps NCOR2, anticorps Ncor2, anticorps ncor2

Sujet: NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.

Poids moléculaire: 275 kDa

ID gène: 9612

NCBI Accession: NP_006303

UniProt: Q9Y618

Pathways: Signalisation Notch, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha