GLUT1 anticorps

N° du produit ABIN265442

Détail du produit anti-GLUT1 anticorps

Antigène: GLUT1 (SLC2A1) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 (SLC2A1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLUT1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects endogenous levels of GLUT1 protein.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/5000approx. 1/40000. Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur GLUT1

Antigène: GLUT1 (SLC2A1) (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 (SLC2A1))

Autre désignation: GLUT1 / SLC2A1 (SLC2A1 Produits)

Synonymes: anticorps DYT17, anticorps DYT18, anticorps DYT9, anticorps EIG12, anticorps GLUT, anticorps GLUT1, anticorps GLUT1DS, anticorps HTLVR, anticorps PED, anticorps Glut-1, anticorps Glut1, anticorps GLUTB, anticorps GTG1, anticorps Gtg3, anticorps RATGTG1, anticorps SLC2A1, anticorps GLT1, anticorps GLUCOSE TRANSPORTER 1, anticorps T21H19.70, anticorps T21H19_70, anticorps plastidic GLC translocator, anticorps glut1, anticorps ped, anticorps slc2a1, anticorps slc2a14, anticorps solute carrier family 2 member 1, anticorps solute carrier family 2 (facilitated glucose transporter), member 1, anticorps plastidic GLC translocator, anticorps solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog, anticorps SLC2A1, anticorps Slc2a1, anticorps PGLCT, anticorps slc2a1.L

Sujet: Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter, Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane, and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve pass transmembrane proteins (12TM) whose carboxytermini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.Synonyms: GLUT-1, Glucose Transporter 1, Glucose transporter type 1, Glucose transporter type 1 erythrocyte/brain, HepG2 glucose transporter, Solute carrier family 2 facilitated glucose transporter member 1

Poids moléculaire: approx. 55 kDa

ID gène: 6513

NCBI Accession: NP_006507

UniProt: P11166

Pathways: Sensory Perception of Sound, Dicarboxylic Acid Transport, L'effet Warburg