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FGFR1 anticorps (N-Term)
FGFR1
Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval
WB
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN2440842
Détail du produit anti-FGFR1 anticorps
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Antigène
Voir toutes FGFR1 Anticorps
FGFR1
(Fibroblast Growth Factor Receptor 1 (FGFR1))
Épitope
Tous les épitopes à travers FGFR1 Anticorps.
N-Term
Reactivité
Toutes les réactivités sur FGFR1 Anticorps
Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval
Hôte
Toutes les hôtes sur FGFR1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur FGFR1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers FGFR1 Anticorps
Cet anticorp FGFR1 est non-conjugé
Application
Tous les applications à travers FGFR1 Anticorps.
Western Blotting (WB)
Séquence
TYFSVNVSDA LPSSEDDDDD DDSSSEEKET DNTKPNRRPV APYWTSPEKM
Homologie
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
Attributs du produit
This is a rabbit polyclonal antibody against Fgfr1. It was validated on Western Blot.
Purification
Affinity Purified
Immunogène
The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Fgfr1
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Discover our top product FGFR1 Anticorps primaire
Alternatives
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Information d'application
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Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeat freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Détails sur FGFR1
(cache)
Antigène
FGFR1
(Fibroblast Growth Factor Receptor 1 (FGFR1))
Autre désignation
Fgfr1 (FGFR1 Produits )
Synonymes
anticorps FGFR, anticorps fgfr, anticorps X1FGFR, anticorps XFGFR-1, anticorps XFGFRA2, anticorps bfgfr, anticorps cek, anticorps fgfr1, anticorps flg, anticorps flt-2, anticorps flt2, anticorps kal2, anticorps ogd, anticorps xfgfr1, anticorps CG7223, anticorps CT22273, anticorps CT39172, anticorps DFGF-R1, anticorps DFGF-R2, anticorps DFR-1, anticorps DFR1, anticorps DFR1/DFGF-R2, anticorps DPR3, anticorps DTRK(FR1), anticorps Dfr-1, anticorps Dfr1, anticorps DmHD-38, anticorps Dmel\\CG7223, anticorps Dtk1, anticorps EMS2, anticorps FGF-R2, anticorps FGFR2, anticorps FR1, anticorps Fr1, anticorps HD-38, anticorps HTL/FGFR1, anticorps Htl, anticorps Tk1, anticorps dtk1, anticorps i100, anticorps i150, anticorps i79, anticorps j372, anticorps cd331, anticorps fgfbr, anticorps fgfr-1, anticorps hbgfr, anticorps n-sam, anticorps ach, anticorps cd333, anticorps cek2, anticorps fgfr-3, anticorps hsfgfr3ex, anticorps jtk4, anticorps BFGFR, anticorps CD331, anticorps CEK, anticorps FGFBR, anticorps FGFR-1, anticorps FLG, anticorps FLT-2, anticorps FLT2, anticorps HBGFR, anticorps HH2, anticorps KAL2, anticorps N-SAM, anticorps OGD, anticorps bFGF-R-1, anticorps AW208770, anticorps Eask, anticorps Fgfr-1, anticorps Flt-2, anticorps Hspy, anticorps FLG-1, anticorps FGFRI, anticorps x1fgfr, anticorps cb231, anticorps sb:cb231, anticorps fibroblast growth factor receptor, anticorps fibroblast growth factor receptor 1 S homeolog, anticorps basic fibroblast growth factor receptor 1, anticorps heartless, anticorps fibroblast growth factor receptor 1, anticorps fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog, anticorps Fibroblast growth factor receptor 1, anticorps fibroblast growth factor receptor 1 L homeolog, anticorps fibroblast growth factor receptor 1a, anticorps FGFR, anticorps fgfr, anticorps fgfr1.S, anticorps CpipJ_CPIJ005849, anticorps htl, anticorps fgfr1, anticorps fgfr3.L, anticorps FGFR1, anticorps Fgfr1, anticorps fgfr1.L, anticorps fgfr1a
Sujet
Fgfr1 is a Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. It is required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Fgfr1 phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. It promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, Fgfr1 enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation Alias Symbols: AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy Protein Interaction Partner: GZMB, Fgf23, Kl, Frs2, Protein Size: 822
Poids moléculaire
92 kDa
ID gène
14182
NCBI Accession
NM_010206 , NP_034336
UniProt
P16092
Pathways
Signalisation RTK , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Sensory Perception of Sound , Stem Cell Maintenance , S100 Proteins
Vus récemment
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