TNFRSF1B anticorps (N-Term)
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- Antigène Voir toutes TNFRSF1B Anticorps
- TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Porc, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TNFRSF1B est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR
- Homologie
- Cow: 86%, Dog: 100%, Guinea Pig: 79%, Horse: 85%, Human: 100%, Mouse: 79%, Pig: 86%, Rabbit: 79%, Rat: 79%
- Attributs du produit
- This is a rabbit polyclonal antibody against TNFRSF1B. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product TNFRSF1B Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 461 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Barrier Perturbation in Porcine Peyer's Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins." dans: Frontiers in physiology, Vol. 13, pp. 889552, (2022) (PubMed).
: "Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1." dans: International journal of molecular sciences, Vol. 22, Issue 16, (2021) (PubMed).
: "
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Barrier Perturbation in Porcine Peyer's Patches by Tumor Necrosis Factor is Associated With a Dysregulation of Claudins." dans: Frontiers in physiology, Vol. 13, pp. 889552, (2022) (PubMed).
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- Antigène
- TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))
- Autre désignation
- TNFRSF1B (TNFRSF1B Produits)
- Synonymes
- anticorps CD120b, anticorps TBPII, anticorps TNF-R-II, anticorps TNF-R75, anticorps TNFBR, anticorps TNFR1B, anticorps TNFR2, anticorps TNFR80, anticorps p75, anticorps p75TNFR, anticorps TNF-RII/TNFRSF1B, anticorps TNFR-II, anticorps TNFRSF1B, anticorps TNF-R2, anticorps TNF-alphaR2, anticorps TNFRII, anticorps TNFalpha-R2, anticorps Tnfr-1, anticorps Tnfr2, anticorps rank, anticorps zgc:163064, anticorps TNF receptor superfamily member 1B, anticorps tumor necrosis factor receptor superfamily, member 1b, anticorps tumor necrosis factor receptor superfamily, member 1B, anticorps TNFRSF1B, anticorps Tnfrsf1b, anticorps tnfrsf1b
- Sujet
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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Alias Symbols: CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Protein Interaction Partner: LTA, TNF, ADAM17, CSNK1A1, ZNF420, UBQLN1, TRAF1, PKN1, CD14, RIPK1, TRADD, TRAF2, TNFRSF1A, CHUK, TRAF6, TRAF3, ASB3, UBC, HIVEP3, TRAIP, TDP2, CAV1, STAT1, BMX, FANCD2, KRT18, SMURF2, TRIM37, TNFRSF1B,
Protein Size: 461 - Poids moléculaire
- 46 kDa
- ID gène
- 7133
- NCBI Accession
- NM_001066, NP_001057
- UniProt
- P20333
- Pathways
- Signalisation NF-kappaB, Apoptose, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway
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