NFKB1 anticorps (C-Term)

N° du produit ABIN3042654

Il existe 12+ publications pour ce produit. L’anticorps anti-NFKB1 Polyclonal Lapin est utilisé pour la détection de NFKB1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et IHC.

Aperçu rapide pour NFKB1 anticorps (C-Term) (ABIN3042654)

Antigène: NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFKB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-NFKB1 anticorps

Épitope: AA 778-797, C-Term

Fonction: Anti-NFkB/NFKB1 p105/p50 Antibody

Séquence: WQVFDILNGK PYEPVFTSDD

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-NFkB/NFKB1 p105/p50 Antibody (ABIN3042654). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of mouse NFkB/NFKB1 p105/p50, identical to the related rat sequence, and different from the related human sequence by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Thimerosal, 0.01 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-NFKB1 (ABIN3042654)

Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." dans: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).

Wu, Gao, Li, Yao, Wang, Chen, Li, Ma, Ji, Li: "Hydrogen Sulfide Mitigates Kidney Injury in High Fat Diet-Induced Obese Mice." dans: Oxidative medicine and cellular longevity, Vol. 2016, pp. 2715718, (2017) (PubMed).

Zhao, Xue, Wang: "HMGB1, TGF-β and NF-κB are associated with chronic allograft nephropathy." dans: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 6138-6146, (2017) (PubMed).

Kan, Zhou, Jin, Yang: "Effects of PDTC on NF-?B expression and apoptosis in rats with severe acute pancreatitis-associated lung injury." dans: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 3258-70, (2015) (PubMed).

Xiao, Gang, Wang, Wang, Zhao, Xu, Liu: "Double-stranded RNA transcribed from vector-based oligodeoxynucleotide acts as transcription factor decoy." dans: Biochemical and biophysical research communications, Vol. 457, Issue 2, pp. 221-6, (2015) (PubMed).

Shang, Chen, Nie, Xu, Chen, Zeng, Zhou: "MiR199b suppresses expression of hypoxia-inducible factor 1α (HIF-1α) in prostate cancer cells." dans: International journal of molecular sciences, Vol. 14, Issue 4, pp. 8422-36, (2015) (PubMed).

Xu, Wang, Wu, Wang: "Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor ?B and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis." dans: Gut and liver, Vol. 9, Issue 3, pp. 411-6, (2015) (PubMed).

Liu, Wang, Qian, Li: "Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis." dans: International journal of molecular medicine, Vol. 34, Issue 6, pp. 1492-504, (2014) (PubMed).

Li, Qian, Ju, Wang: "Upregulation of Toll-like receptor 2 expression in colorectal cancer infected by human cytomegalovirus." dans: Oncology letters, Vol. 9, Issue 1, pp. 365-370, (2014) (PubMed).

Zhao, Wang, Liu, Sun, Kazuhiro: "Protective effects of glutamine in a rat model of endotoxemia." dans: Molecular medicine reports, Vol. 6, Issue 4, pp. 739-44, (2012) (PubMed).

Leng, Liu, Yang, Cui, Li, Zhu, Xiong, Zhang, Chen: "The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells." dans: Cell biology international, Vol. 36, Issue 10, pp. 893-9, (2012) (PubMed).

Li, Chen, Zhang, Zhu, Liu, Liang, Sun, Liao, Gong: "Protective effect of glutamine-enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats." dans: American journal of surgery, Vol. 199, Issue 1, pp. 35-42, (2010) (PubMed).

Détails sur NFKB1

Antigène: NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))

Autre désignation: NFKB1

Sujet:

Synonyms: Nuclear factor NF-kappa-B p105 subunit,DNA-binding factor KBF1,EBP-1,NF-kappa-B1 p84/NF-kappa-B1 p98,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,Nuclear factor NF-kappa-B p50 subunit,Nfkb1,

Tissue Specificity: Major component of lens fiber gap junctions.

Background: Nuclear factor NF-kappa-B p105 subunit, also called EBP-1 is a protein that in humans is encoded by the NFKB1 gene. By fluorescence in situ hybridization, the gene was assigned to human chromosome 4q24. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing.

Sequence Similarities: Contains 7 ANK repeats.

Poids moléculaire: 50, 120kDa

UniProt: P25799

Pathways: Signalisation p53, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins