SOCS1 anticorps (C-Term)

N° du produit ABIN3044331

Détail du produit anti-SOCS1 anticorps

Antigène: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Épitope: AA 197-211, C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOCS1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 1(SOCS1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: NPVLRDYLSS FPFQI

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 1(SOCS1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: suppressor of cytokine signaling 1
Protein Name: Suppressor of cytokine signaling 1(SOCS-1)

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS1(197-211aa NPVLRDYLSSFPFQI), identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-SOCS1 (ABIN3044331)

Yang, Tian, Zhang, Xu, Yang, Yu, Li, Li, Li, Li: "Role of the JAK2/STAT3 signaling pathway in the pathogenesis of type 2 diabetes mellitus with macrovascular complications." dans: Oncotarget, Vol. 8, Issue 57, pp. 96958-96969, (2017) (PubMed).

Wan, Ma, Mei, Shan: "The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells." dans: Journal of experimental & clinical cancer research : CR, Vol. 28, pp. 150, (2010) (PubMed).

Détails sur SOCS1

Antigène: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Autre désignation: SOCS1 (SOCS1 Produits)

Synonymes: anticorps socs1, anticorps zgc:91868, anticorps jab, anticorps cis1, anticorps ssi1, anticorps tip3, anticorps cish1, anticorps ssi-1, anticorps socs-1, anticorps SOCS1, anticorps LOC100228306, anticorps socs1b, anticorps CIS1, anticorps CISH1, anticorps JAB, anticorps SOCS-1, anticorps SSI-1, anticorps SSI1, anticorps TIP3, anticorps Cish1, anticorps Cish7, anticorps Socs-1, anticorps suppressor of cytokine signaling 1a, anticorps suppressor of cytokine signaling 1, anticorps suppressor of cytokine signaling 1 L homeolog, anticorps socs1a, anticorps socs1, anticorps SOCS1, anticorps socs1.L, anticorps Socs1

Sujet: Suppressor of cytokine signaling 1(SOCS1), also known as Jak-binding protein(JAB), is a negative regulator to a subset of protein-tyrosine kinases. This 211-amino acid protein has a molecular mass of about 23.5 kD. The TEC-binding region of SOCS1 resides in the N terminus. SOCS1 associates with Tec and suppresses its kinase activity. The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13. SOCS1 regulates the JAK/STAT signal-transduction pathway. Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.

Synonyms: CISH 1 antibody|CISH1 antibody|Cytokine Inducible SH2 Protein 1 antibody|JAB antibody|JAK Binding Protein antibody|JAK-binding protein antibody|Janus kinase binding protein antibody|SOCS 1 antibody|SOCS-1 antibody|Socs1 antibody|SOCS1_HUMAN antibody|SSI 1 antibody|SSI-1 antibody|SSI1 antibody|STAT Induced STAT Inhibitor 1 antibody|STAT-induced STAT inhibitor 1 antibody|Suppressor of cytokine signaling 1 antibody|Supressor of cytokine Signalling 1 antibody|TEC Interacting Protein 3 antibody|Tec-interacting protein 3 antibody|TIP 3 antibody|TIP-3 antibody|TIP3 antibody

UniProt: O15524

Pathways: Signalistation JAK/STAT, Interferon-gamma Pathway, Signalisation TLR, Response to Growth Hormone Stimulus