IFNB1 anticorps (Middle Region)

N° du produit ABIN318888

Détail du produit anti-IFNB1 anticorps

Antigène: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Épitope: Middle Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFNB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody recognises interferon beta (IFN-beta), a 22 kDa member of the type I alpha/beta interferon family.

Réactivité croisée (Details): Species reactivity (tested):Human and Mouse.

Purification: Purified

Immunogène: A 17 amino acid peptide located near the centre of human Interferon beta.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 5 μg/mL. This Interferon beta antibody detects a band of approximately 15 kDa in A20 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur IFNB1

Antigène: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Autre désignation: IFNB / Interferon beta (IFNB1 Produits)

Synonymes: anticorps IFB, anticorps IFF, anticorps IFNB, anticorps IFN-beta, anticorps Ifb, anticorps Ifnb, anticorps IFNb, anticorps interferon beta 1, anticorps interferon beta 1, fibroblast, anticorps interferon, beta 1, fibroblast, anticorps IFNB1, anticorps Ifnb1

Sujet: The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50 % amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.Synonyms: Fibroblast interferon, IFB, IFN-beta, IFNB1

ID gène: 3456

NCBI Accession: NP_002167

UniProt: P01574

Pathways: Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome