PRKAR2B anticorps (N-Term)

N° du produit ABIN359121

Détail du produit anti-PRKAR2B anticorps

Antigène: PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAR2B est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to PKA 2 beta (PRKAR2B).

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PRKAR2B.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100- 1/500. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur PRKAR2B

Antigène: PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))

Autre désignation: PRKAR2B (PRKAR2B Produits)

Synonymes: anticorps MGC83177, anticorps PRKAR2B, anticorps AI451071, anticorps AW061005, anticorps PKARIIbeta, anticorps Pkarb2, anticorps RII(beta), anticorps RATDNA, anticorps PRKAR2, anticorps RII-BETA, anticorps protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog, anticorps protein kinase cAMP-dependent type II regulatory subunit beta, anticorps protein kinase, cAMP-dependent, regulatory, type II, beta, anticorps protein kinase, cAMP dependent regulatory, type II beta, anticorps protein kinase cAMP-dependent type 2 regulatory subunit beta, anticorps prkar2b.S, anticorps PRKAR2B, anticorps prkar2b, anticorps Prkar2b

Sujet: CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.Synonyms: PRKAR2, cAMP-dependent protein kinase type II-beta regulatory subunit

ID gène: 5577, 5874

UniProt: P31323

Pathways: Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2