PPM1D anticorps (C-Term)

N° du produit ABIN360767

Détail du produit anti-PPM1D anticorps

Antigène: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPM1D est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to PPM1D.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PPM1D.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur PPM1D

Antigène: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Autre désignation: Protein Phosphatase 1D / PPM1D (PPM1D Produits)

Synonymes: anticorps PP2C-DELTA, anticorps WIP1, anticorps AV338790, anticorps Wip1, anticorps zgc:103518, anticorps ppm1d, anticorps wu:fj44c08, anticorps zgc:55836, anticorps zgc:77316, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1D, anticorps protein phosphatase 1D magnesium-dependent, delta isoform, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1D, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1Db, anticorps protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog, anticorps protein phosphatase, Mg2+/Mn2+ dependent, 1Da, anticorps PPM1D, anticorps Ppm1d, anticorps ppm1db, anticorps ppm1d.L, anticorps ppm1da

Sujet: PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negativelyregulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stressinduced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.Synonyms: PP2C-delta, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium-dependent 1 delta, WIP1, p53-induced protein phosphatase 1

ID gène: 8493, 9606

UniProt: O15297

Pathways: Signalisation p53, Cycle Cellulaire