TRIM29 anticorps (Internal Region)

N° du produit ABIN401461

Détail du produit anti-TRIM29 anticorps

Antigène: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Macaque, Chimpanzé

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM29 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts with over-expressed, acetylated lysine ATDC protein.

Réactivité croisée (Details): Species reactivity (expected):Horse, Cattle, Chimpanzee, Macaque, Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogène: Peptide corresponding to an internal portion of human ATDC protein around lysine 116

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/100,000. Western Blot: 1/500 - 1/3,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.67 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Détails sur TRIM29

Antigène: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Autre désignation: TRIM29 / ATDC (TRIM29 Produits)

Synonymes: anticorps ATDC, anticorps 1110047J21Rik, anticorps 2810431N19Rik, anticorps 4732461M22Rik, anticorps AI119726, anticorps MGC53484, anticorps TRIM29, anticorps atdc, anticorps tripartite motif containing 29, anticorps tripartite motif-containing 29, anticorps tripartite motif containing 29 L homeolog, anticorps TRIM29, anticorps Trim29, anticorps trim29.L, anticorps trim29

Sujet: Ataxiatelangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.Synonyms: Ataxia-telangiectasia group D-associated protein, Tripartite motif-containing protein 29

ID gène: 23650

NCBI Accession: NP_036233

UniProt: Q14134

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus