NPC2 anticorps (Internal Region)

N° du produit ABIN498021

Détail du produit anti-NPC2 anticorps

Antigène: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Épitope: Internal Region

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp NPC2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Séquence: QAEPVQFKDC GSVD

Specificité: Recognizes Niemann-Pick disease type C2 NPC2.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_006423.1. Genename: NPC2

Information d'application

Indications d'application: Peptide ELISA: Limit Dilution: 1/2000. Western blot: 0.3-1 μg/mL. Experiments gave bands at approx 20 kDa and 20 kDa in HumanTestis lysates. These bands correspond to earlier findings in literature with differentantibodies (Ref.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur NPC2

Antigène: NPC2 (Niemann-Pick Disease, Type C2 (NPC2))

Autre désignation: NPC2 (NPC2 Produits)

Synonymes: anticorps 2700012J19Rik, anticorps AA408070, anticorps AU045843, anticorps HE1, anticorps EDDM1, anticorps re1, anticorps CE1, anticorps EPI-1, anticorps cb292, anticorps sb:cb292, anticorps NPC intracellular cholesterol transporter 2, anticorps Niemann-Pick disease, type C2, anticorps Npc2, anticorps NPC2, anticorps npc2

Sujet: Niemann-Pick C2 (NPC2) is a 22 kDa soluble lysosomal glycoprotein important for cholesterol and sphingolipid transport in the lysosome. This protein was initially identified as the second Niemann-Pick type C (NPC) gene based on its ability to bind the mannose-6 phosphate receptor. NPC disease is an autosomal recessively inherited neurodegenerative lysosomal storage disease and its associated with abnormal cholesterol accumulation in cells. Mutations in the NPC2 gene cause 5 % of the cases, the rest and majority being caused by NPC1 mutations.Synonyms: Epididymal secretory protein E1

ID gène: 10577

NCBI Accession: NP_006423

UniProt: P61916

Pathways: SARS-CoV-2 Protein Interactome