FYN anticorps (pTyr530)
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- Antigène Voir toutes FYN Anticorps
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
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Épitope
- pTyr530
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FYN est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of p-Fyn protein.
- Purification
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product FYN Anticorps primaire
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- Indications d'application
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Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
- Autre désignation
- FYN (FYN Produits)
- Synonymes
- anticorps im:6908851, anticorps si:dkey-119m7.5, anticorps zgc:109996, anticorps c-fyn, anticorps cfyn-a, anticorps SLK, anticorps SYN, anticorps p59-FYN, anticorps PKC, anticorps fyn, anticorps zgc:86720, anticorps AI448320, anticorps AW552119, anticorps FYN proto-oncogene, Src family tyrosine kinase, anticorps FYN proto-oncogene, Src family tyrosine kinase S homeolog, anticorps FYN proto-oncogene, Src family tyrosine kinase b, anticorps FYN proto-oncogene, Src family tyrosine kinase L homeolog, anticorps FYN proto-oncogene, Src family tyrosine kinase a, anticorps Fyn proto-oncogene, anticorps FYN, anticorps fyn.S, anticorps fynb, anticorps fyn.L, anticorps Fyn, anticorps fyna
- Sujet
- Fyn is a membrane-associated, non-receptor protein tyrosine kinase approximately 59 kDa, which belongs to the Src family of cytoplasmic tyrosine kinases. Fyn is very strongly similar to mouse Fyn, v-yes and c-src. Fyn is expressed predominately in tissues of neuronal and hematopoietic origin. Neuronal Fyn and hematopoietic Fyn differ at the junction of the SH2 and kinase domains due to tissue specific alternative splicing. Fyn has been shown to be involved in B cell and T cell activation as well as keratinocyte differentiation. In T cells, Fyn associates with the T-cell antigen receptor and Thy1.The unique N terminal domain of Fyn interacts with the CD3 and eta chains of the TcR. Fyn can bind to other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of Fyn activity. Fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation.Synonyms: Proto-oncogene tyrosine-protein kinase Fyn, Protooncogene Syn, SLK, p59-Fyn
- Poids moléculaire
- approx. 59 kDa
- ID gène
- 2534
- NCBI Accession
- NP_002028
- UniProt
- P06241
- Pathways
- Signalistation JAK/STAT, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
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