APH1A anticorps (AA 11-245)

N° du produit ABIN5027035

Détail du produit anti-APH1A anticorps

Antigène: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Épitope: AA 11-245

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APH1A est non-conjugé

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogène: A partial length recombinant APH1A protein (amino acids 11-245) was used as the immunogen for this antibody.

Isotype: IgG

Information d'application

Indications d'application: WB: 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Détails sur APH1A

Antigène: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Autre désignation: APH1A (APH1A Produits)

Synonymes: anticorps 6530402N02Rik, anticorps APH-1, anticorps APH-1A, anticorps CGI-78, anticorps RGD1311546, anticorps APH-1a, anticorps aph-1 homolog A, gamma-secretase subunit, anticorps aph-1 homolog A, gamma secretase subunit L homeolog, anticorps aph-1 homolog A, gamma secretase subunit, anticorps anterior pharynx defective 1 homolog A (C. elegans), anticorps aph1 homolog A, gamma secretase subunit, anticorps acylamino-acid-releasing enzyme-like, anticorps APH1A, anticorps aph1a.L, anticorps Aph1a, anticorps LOC100219182

Sujet: APH1A also known as Anterior pharynx-defective 1, is a multi-spanning membrane protein and an integral component of the high molecular weight gamma-secretase complex that also contains presenilin, nicastrin, and Pen-2. The gamma-secretase complex is required for the intramembrane proteolysis of APP (amyloid-beta precursor protein) and Notch. APH1A is essential for gamma-cleavage of APP to enable the intracellular domain to travel to the nucleus. APH1A satisfies three major criteria for a subunit of the gamma-secretase complex in mammalian cells. First, endogenous APH1A, nicastrin, and the presenilin NTF:CTF heterodimers physically interact with each other in vivo and under the conditions that are compatible with gamma-secretase activity. Second, like presenilin and nicastrin, APH1A is required for the intramembrane proteolysis of both APP and Notch. Third, the down-regulation of APH1A like presenilin or nicastrin leads to concurrent reduction of the mature nicastrin or the steady-state levels of the presenilin endoproteolytic fragments, the mature presenilin species within the gamma-secretase complex.

Poids moléculaire: 27 kDa

ID gène: 51107

UniProt: Q96BI3

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway