EGLN1 anticorps (AA 1-50)

N° du produit ABIN504713

Détail du produit anti-EGLN1 anticorps

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Épitope: AA 1-50

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EGLN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Réactivité croisée: Boeuf (Vache), Humain, Rat (Rattus)

Purification: Aff - Purified

Immunogène: A peptide within AA 1-50 of the human protein. [Swiss-Prot# Q9GZT9].

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Détails sur EGLN1

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Autre désignation: HIF Prolyl Hydroxylase 2 (EGLN1 Produits)

Synonymes: anticorps EGLN1, anticorps egln2, anticorps phd2, anticorps zgc:92314, anticorps AI503754, anticorps C1orf12, anticorps HIF-PH2, anticorps HPH-2, anticorps Hif-p4h-2, anticorps ORF13, anticorps Phd2, anticorps SM-20, anticorps PHD-2, anticorps PHD2, anticorps ECYT3, anticorps HIFPH2, anticorps HPH2, anticorps SM20, anticorps ZMYND6, anticorps egl nine homolog 1 (C. elegans), anticorps egl-9 family hypoxia inducible factor 1, anticorps egl-9 family hypoxia-inducible factor 1 S homeolog, anticorps egl-9 family hypoxia-inducible factor 1b, anticorps egl-9 family hypoxia-inducible factor 1, anticorps EGLN1, anticorps egln1.S, anticorps egln1b, anticorps Egln1

Sujet: HIF prolyl hydroxylase 2 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the HPH sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. HPH is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, HPHs convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. HPH-2, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It hydroxylates HIF-1 alpha at Pro(402) and Pro(564), and HIF-2 alpha. It targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

UniProt: Q9GZT9

Pathways: cAMP Metabolic Process, L'effet Warburg