MDM2 anticorps (pSer185)

N° du produit ABIN538477

Détail du produit anti-MDM2 anticorps

Antigène: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Épitope: pSer185

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MDM2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Fonction: Rabbit polyclonal antibody raised against synthetic phosphopeptide of Mdm2.

Specificité: Reactivity occurs against Mouse MDM2 pS185 protein and This antibody is specific to the phosphorylated form of the protein. Reactivity with non-phosphorylated mouse MDM2 is minimal by ELISA and western blot.

Réactivité croisée: Souris

Attributs du produit: Antibody Reactive Against Synthetic Peptide.

Immunogène: Synthetic phosphopeptide corresponding to residues surrounding S185 of mouse Mdm2.

Information d'application

Indications d'application: ELISA (1:3000-1:12000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 20 mM KH₂PO₄, 150 mM NaCl, pH 7.2 (0.01 % sodium azide)

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-MDM2 (ABIN538477)

Stros, Muselíková-Polanská, Pospísilová, Strauss: "High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops." dans: Biochemistry, Vol. 43, Issue 22, pp. 7215-25, (2004) (PubMed).

Aslanian, Iaquinta, Verona, Lees: "Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics." dans: Genes & development, Vol. 18, Issue 12, pp. 1413-22, (2004) (PubMed).

Pospísilová, Siligan, Ban, Jug, Kovar: "Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y." dans: Molecular cancer research : MCR, Vol. 2, Issue 5, pp. 296-304, (2004) (PubMed).

Détails sur MDM2

Antigène: MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2))

Autre désignation: MDM2 (MDM2 Produits)

Synonymes: anticorps ACTFS, anticorps HDMX, anticorps hdm2, anticorps zgc:109834, anticorps 1700007J15Rik, anticorps AA415488, anticorps Mdm-2, anticorps MDM2 proto-oncogene, anticorps MDM2 proto-oncogene S homeolog, anticorps Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse), anticorps MDM2 oncogene, E3 ubiquitin protein ligase, anticorps transformed mouse 3T3 cell double minute 2, anticorps MDM2, anticorps mdm2.S, anticorps Mdm2, anticorps mdm2

ID gène: 17246

Pathways: Signalisation p53, Signalisation PI3K-Akt, Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Autophagy, Ubiquitin Proteasome Pathway