BRAF anticorps (pSer446)

N° du produit ABIN548454

Détail du produit anti-BRAF anticorps

Antigène: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Épitope: pSer446

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRAF est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRAF .

Specificité: This sequence is conserved in B-Rafs from many species, and has high homology to C-Raf (Ser-338) and A-Raf (Ser-299).

Réactivité croisée: Humain, Souris, Rat

Immunogène: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S446 of human BRAF. This sequence is conserved in B-Rafs from many species, and has high homology to C-Raf (Ser-338) and A-Raf (Ser-299).

Information d'application

Indications d'application: ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In PBS (50 % glycerol, 1 mg/mL BSA, 0.05 % sodium azide).

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-BRAF (ABIN548454)

Brummer, Martin, Herzog, Misawa, Daly, Reth: "Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein." dans: Oncogene, Vol. 25, Issue 47, pp. 6262-76, (2006) (PubMed).

Karbowniczek, Robertson, Henske: "Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization." dans: The Journal of biological chemistry, Vol. 281, Issue 35, pp. 25447-56, (2006) (PubMed).

Wilhelm, Carter, Tang, Wilkie, McNabola, Rong, Chen, Zhang, Vincent, McHugh, Cao, Shujath, Gawlak, Eveleigh, Rowley, Liu, Adnane, Lynch, Auclair, Taylor, Gedrich, Voznesensky, Riedl, Post, Bollag et al.: "BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. ..." dans: Cancer research, Vol. 64, Issue 19, pp. 7099-109, (2004) (PubMed).

Détails sur BRAF

Antigène: BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))

Autre désignation: B-Raf proto-oncogene (BRAF Produits)

Synonymes: anticorps B-RAF1, anticorps BRAF1, anticorps NS7, anticorps RAFB1, anticorps C-RMIL, anticorps RMIL, anticorps B-Raf, anticorps braf1, anticorps rafb1, anticorps b-raf1, anticorps sierrabraf, anticorps BRAF, anticorps 9930012E13Rik, anticorps AA120551, anticorps AA387315, anticorps AA473386, anticorps B-raf, anticorps Braf-2, anticorps Braf2, anticorps C230098H17, anticorps C87398, anticorps D6Ertd631e, anticorps braf, anticorps fc48g01, anticorps wu:fc48g01, anticorps B-Raf proto-oncogene, serine/threonine kinase, anticorps B-Raf proto-oncogene, serine/threonine kinase S homeolog, anticorps Braf transforming gene, anticorps si:dkey-222f8.3, anticorps BRAF, anticorps Braf, anticorps braf.S, anticorps braf, anticorps si:dkey-222f8.3

ID gène: 673

Pathways: Signalisation MAPK, Signalisation RTK, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagy