SHP1 anticorps (pSer591)

N° du produit ABIN548474

Détail du produit anti-SHP1 anticorps

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Épitope: pSer591

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTPN6.

Specificité: The sequence is highly conserved in rat and mouse SHP1.

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Antibody Reactive Against Synthetic Peptide.

Immunogène: Synthetic phosphopeptide corresponding to residues surrounding S591 of human PTPN6.

Information d'application

Indications d'application: ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In PBS (50 % glycerol, 1 mg/mL BSA, 0.05 % sodium azide)

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-SHP1 (ABIN548474)

Simoneau, Boulanger, Coulombe, Renaud, Duchesne, Rivard: "Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells." dans: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25544-56, (2008) (PubMed).

Jones, Craik, Gibbins, Poole: "Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus." dans: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40475-83, (2004) (PubMed).

Zhang, Shen, Lu, Cole: "The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation." dans: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 4668-74, (2003) (PubMed).

Détails sur SHP1

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Autre désignation: PTPN6 (PTPN6 Produits)

Synonymes: anticorps HCPH, anticorps HPTP1C, anticorps PTP-1C, anticorps SH-PTP1, anticorps SHP-1, anticorps SHP-1L, anticorps SHP1, anticorps DRPLA, anticorps Hcph, anticorps Ptp1C, anticorps me, anticorps motheaten, anticorps Ptph6, anticorps Shp-1, anticorps fj22f05, anticorps wu:fj22f05, anticorps zgc:55501, anticorps ptpn6, anticorps protein tyrosine phosphatase, non-receptor type 6, anticorps protein tyrosine phosphatase, non-receptor type 6 L homeolog, anticorps PTPN6, anticorps Ptpn6, anticorps ptpn6, anticorps ptpn6.L

ID gène: 5777

Pathways: Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling