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ERK1 anticorps (pThr202, Tyr204)

MAPK3 Reactivité: Humain, Souris, Rat, Poulet, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Xenopus laevis, Non-Human Primate WB, IF, IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN372623
  • Antigène Voir toutes ERK1 (MAPK3) Anticorps
    ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))
    Épitope
    • 79
    • 55
    • 23
    • 23
    • 16
    • 15
    • 15
    • 14
    • 11
    • 11
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    • 3
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    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr202, Tyr204
    Reactivité
    • 254
    • 176
    • 147
    • 45
    • 20
    • 19
    • 17
    • 12
    • 12
    • 11
    • 11
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Poulet, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Xenopus laevis, Non-Human Primate
    Hôte
    • 262
    • 29
    • 4
    • 1
    • 1
    Lapin
    Clonalité
    • 238
    • 59
    Polyclonal
    Conjugué
    • 121
    • 25
    • 22
    • 20
    • 13
    • 11
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    Cet anticorp ERK1 est non-conjugé
    Application
    • 249
    • 104
    • 87
    • 68
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    • 47
    • 42
    • 39
    • 36
    • 25
    • 17
    • 12
    • 12
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    Recognizes the ~42k-44k ERK/MAPK phosphorylated at Thr202 and Tyr204. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. The immunolabeling is completely eliminated by lambda-phosphatase.
    Réactivité croisée (Details)
    Species reactivity (expected):Bovine, Canine, Chicken, Mouse, non-Human Primates, Xenopus and ZebrafishSpecies reactivity (tested):Human and Rat.
    Purification
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    Immunogène
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr202 and Tyr204 of rat ERK/MAPK.
    Isotype
    IgG
    Top Product
    Discover our top product MAPK3 Anticorps primaire
  • Indications d'application
    Western Blot: 1/1000. Immunohistochemistry: 1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Chaudhuri, Ghate, Singh, Mandal: "Methyl gallate isolated from Spondias pinnata exhibits anticancer activity against human glioblastoma by induction of apoptosis and sustained extracellular signal-regulated kinase 1/2 activation." dans: Pharmacognosy magazine, Vol. 11, Issue 42, pp. 269-76, (2015) (PubMed).

  • Antigène
    ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))
    Autre désignation
    MAPK3 / ERK1 (MAPK3 Produits)
    Synonymes
    anticorps ERK-1, anticorps ERK1, anticorps ERT2, anticorps HS44KDAP, anticorps HUMKER1A, anticorps P44ERK1, anticorps P44MAPK, anticorps PRKM3, anticorps p44-ERK1, anticorps p44-MAPK, anticorps Erk-1, anticorps Erk1, anticorps Ert2, anticorps Esrk1, anticorps Mnk1, anticorps Mtap2k, anticorps Prkm3, anticorps p44, anticorps p44erk1, anticorps p44mapk, anticorps ERK3, anticorps ERK6, anticorps P38GAMMA, anticorps PRKM12, anticorps SAPK-3, anticorps SAPK3, anticorps fi06b09, anticorps wu:fi06b09, anticorps zERK1, anticorps Tb08.10J17.940, anticorps MAPK1, anticorps MNK1, anticorps AW123708, anticorps Erk6, anticorps P38gamma, anticorps Prkm12, anticorps Sapk3, anticorps ATMAPK3, anticorps ATMPK3, anticorps T6D9.4, anticorps mitogen-activated protein kinase 3, anticorps mitogen-activated protein kinase 3, anticorps mitogen-activated protein kinase 12, anticorps mitogen activated protein kinase 3, anticorps mitogen-activated serine/threonine-protein kinase, anticorps MAPK3, anticorps Mapk3, anticorps MAPK12, anticorps mapk3, anticorps Tc00.1047053509475.10, anticorps Tb927.8.3550, anticorps Mapk12, anticorps CEK1, anticorps MPK3
    Sujet
    Extracellular-Signal Regulated Kinase/Mitogen-Activated Protein Kinase (ERK/MAPK) is an integral component of cellular signaling during mitogenesis and differentiation of mitotic cells and also is thought to play a key role in learning and memory (Adams and Sweatt, 2002, Ahn, 1993, Tanoue and Nishida, 2003, Johnson and Lapadat, 2002). The activity of this kinase is regulated by dual phosphorylation at Thr202 and Tyr204 (Ahn, 1993).Synonyms: ERK-1, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 3, PRKM3, p44-ERK1, p44-MAPK
    ID gène
    5595
    NCBI Accession
    NP_002737
    UniProt
    P27361
    Pathways
    Signalisation MAPK, Signalisation RTK, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteins
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