TLR4 anticorps (AA 45-320) (FITC)

N° du produit ABIN5564270

Détail du produit anti-TLR4 anticorps (FITC)

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Épitope: AA 45-320

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TLR4 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Specificité: Recognizes human TLR4.

Réactivité croisée: Humain

Purification: Protein G purified.

Immunogène: Recombinant human TLR4 protein (aa 45-320).

Clone: ABM19C4

Isotype: IgG2b

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In 10 mM TRIS containing 150 mM NaCl and 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: +4°C
Stable for at least 6 months after receipt when stored at +4°C.

Date de péremption: 6 months

Détails sur TLR4

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Autre désignation: TLR4 (TLR4 Produits)

Synonymes: anticorps ARMD10, anticorps CD284, anticorps TLR-4, anticorps TOLL, anticorps Lps, anticorps Ly87, anticorps Ran/M1, anticorps Rasl2-8, anticorps toll like receptor 4, anticorps toll-like receptor 4, anticorps TLR4, anticorps Tlr4

Sujet: TLR4 (Toll-like Receptor 4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. It was the first TLR identified TLR in mammals and most studied member of the TLR family. TLR4 recognizes the active lipid A component of lipopolysaccharide (LPS) from Gram-negative bacteria in conjunction with LY96 (also referred to MD-2), CD14 and LPS-binding protein (LBP) and consequently mediates the innate immune response to bacterial lipopolysaccharide (LPS). Additionally, it is also involved in LPS-independent responses triggered by endogenous DMAPs, such as heat shock proteins (HSPs) or HMGB1. TLR4 signals via MYD88, TIRAP and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response in various cell types. In complex with TLR6, it was shown to promote sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. TLR4-mediated inflammation, triggered by exogenous or endogenous ligands, is involved in several acute and chronic diseases, having a pivotal role as amplifier of the inflammatory response. The potency with which this TLR activates inflammatory pathways makes it an ideal target for therapeutic intervention and adjuvant development. A broad range of clinical studies have examined the adjuvant activity of TLR4 activators in vaccines against infectious and tumor antigens.

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins