IKK alpha anticorps (AA 21-25)

N° du produit ABIN5689587

Cet anticorps Lapin Polyclonal détecte spécifiquement IKK alpha dans WB et IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour IKK alpha anticorps (AA 21-25) (ABIN5689587)

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKK alpha est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-IKK alpha anticorps

Épitope: AA 21-25

Specificité: This antibody detects endogenous level of total IKKα, protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: IKK a (Ab-23) antibody was raised against a peptide sequence around aa.21~25 (L-G-T-G-G) derived from Human IKK α,.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur IKK alpha

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Autre désignation: IKK a

Sujet: Acts as part of the IKK complex in the conventional pathway of NF-κ,-B activation and phosphorylates inhibitors of NF-κ,-B thus leading to the dissociation of the inhibitor/NF-κ,-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-κ,-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-κ,-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-κ,-B-regulated promoters during inflammatory responses triggered by cytokines.

Poids moléculaire: 85 kDa

ID gène: 1147

NCBI Accession: NP_001269

UniProt: O15111

Pathways: Signalisation PI3K-Akt, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins