TRIM29 anticorps (Internal Region)

N° du produit ABIN615933

Détail du produit anti-TRIM29 anticorps

Antigène: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM29 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Séquence: C-EKDRIKSFTT NE

Specificité: This antibody recognizes TRIM29.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogène: Peptide with sequence from the internal region of the protein sequence according to NP_036233.2. Genename: TRIM29

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur TRIM29

Antigène: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Autre désignation: TRIM29 / ATDC (TRIM29 Produits)

Synonymes: anticorps ATDC, anticorps 1110047J21Rik, anticorps 2810431N19Rik, anticorps 4732461M22Rik, anticorps AI119726, anticorps MGC53484, anticorps TRIM29, anticorps atdc, anticorps tripartite motif containing 29, anticorps tripartite motif-containing 29, anticorps tripartite motif containing 29 L homeolog, anticorps TRIM29, anticorps Trim29, anticorps trim29.L, anticorps trim29

Sujet: Ataxia-telangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.Synonyms: Ataxia-telangiectasia group D-associated protein, Tripartite motif-containing protein 29

ID gène: 23650

NCBI Accession: NP_036233

UniProt: Q14134

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus