GADD34 anticorps

N° du produit ABIN6261868

Détail du produit anti-GADD34 anticorps

Antigène: GADD34 (PPP1R15A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GADD34 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: GADD34 Antibody detects endogenous levels of total GADD34.

Homologie: Pig,Bovine,Horse,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human GADD34

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur GADD34

Antigène: GADD34 (PPP1R15A) (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A (PPP1R15A))

Autre désignation: PPP1R15A (PPP1R15A Produits)

Synonymes: anticorps 9630030H21, anticorps Gadd34, anticorps Myd116, anticorps GADD34, anticorps Peg-3, anticorps RGD1624209, anticorps protein phosphatase 1 regulatory subunit 15A, anticorps protein phosphatase 1, regulatory (inhibitor) subunit 15A, anticorps protein phosphatase 1, regulatory subunit 15A, anticorps PPP1R15A, anticorps Ppp1r15a

Sujet:

Description: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.

Gene: PPP1R15A

Poids moléculaire: 100 kDa

ID gène: 23645

UniProt: O75807

Pathways: ER-Nucleus Signaling, Unfolded Protein Response