IKK alpha anticorps (pSer180, pSer181)

N° du produit ABIN7138454

Cet anticorps Lapin Polyclonal détecte spécifiquement IKK alpha dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour IKK alpha anticorps (pSer180, pSer181) (ABIN7138454)

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IKK alpha est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-IKK alpha anticorps

Épitope: pSer180, pSer181

Fonction: Phospho-CHUK/IKBKB (Ser180/181) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 180/181 (C-T-S(p)-F-V) derived from Human IKK- alpha/ beta.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IKK alpha

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Autre désignation: CHUK

Sujet:

Background:

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.

Hafeez BB, et al. (2008) Cancer Res 68, 8564-72
Cahill CM, Rogers JT (2008) J Biol Chem 283, 25900-12
Encinas M, et al. (2008)Cell Death Differ 15, 1510-21

Aliases: chuk antibody, CHUK1 antibody, Conserved Helix Loop Helix Ubiquitous Kinase antibody, Conserved helix loop ubiquitous kinase antibody, Conserved helix-loop-helix ubiquitous kinase antibody, I Kappa B Kinase 1 antibody, I Kappa B Kinase Alpha antibody, I-kappa-B kinase 1 antibody, I-kappa-B kinase alpha antibody, IkappaB kinase antibody, IkB kinase alpha subunit antibody, IkBKA antibody, IKK 1 antibody, IKK A antibody, IKK a kinase antibody, IKK-A antibody, IKK-alpha antibody, IKK1 antibody, IKKA antibody, IKKA_HUMAN antibody, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody, Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody, Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody, NFKBIKA antibody, Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody, Nuclear factor NF kappa B inhibitor kinase alpha antibody, Nuclear factor NF-kappa-B inhibitor kinase alpha antibody, Nuclear factor NFkappaB inhibitor kinase alpha antibody, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody, TCF-16 antibody, TCF16 antibody, Transcription factor 16 antibody

UniProt: O15111

Pathways: Signalisation PI3K-Akt, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins