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NOTCH3 anticorps (C-Term)
NOTCH3
Reactivité: Humain, Souris, Rat
IHC (p), EIA
Hôte: Chèvre
Polyclonal
unconjugated
Détail du produit anti-NOTCH3 anticorps
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Antigène
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NOTCH3
(Notch 3 (NOTCH3))
Épitope
Tous les épitopes à travers NOTCH3 Anticorps.
C-Term
Reactivité
Toutes les réactivités sur NOTCH3 Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur NOTCH3 Anticorps
Chèvre
Clonalité
Toutes les clonalités sur NOTCH3 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers NOTCH3 Anticorps
Cet anticorp NOTCH3 est non-conjugé
Application
Tous les applications à travers NOTCH3 Anticorps.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Séquence
C-QLGPQPEVTP KRQ
Specificité
Recognizes NOTCH3
Réactivité croisée (Details)
Species reactivity (expected):Mouse, Rat. Species reactivity (tested):Human.
Purification
Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Immunogène
Peptide with sequence from the C Terminus of the protein sequence according to NP_000426.2.
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Détails sur NOTCH3
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Antigène
NOTCH3
(Notch 3 (NOTCH3))
Autre désignation
NOTCH3 (NOTCH3 Produits )
Synonymes
anticorps CADASIL, anticorps CASIL, anticorps IMF2, anticorps AW229011, anticorps N3, anticorps hpbk, anticorps fa14b08, anticorps notch5, anticorps wu:fa14b08, anticorps notch 3, anticorps NOTCH3, anticorps Notch3, anticorps notch3
Sujet
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).Synonyms: Neurogenic locus notch homolog protein 3, Notch-3
ID gène
4854
NCBI Accession
NP_000426
Pathways
Signalisation Notch
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