FOXO1 anticorps (AA 201-300) (Alexa Fluor 555)

N° du produit ABIN897569

Détail du produit anti-FOXO1 anticorps (Alexa Fluor 555)

Antigène: FOXO1 (Forkhead Box O1 (FOXO1))

Épitope: AA 201-300

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXO1 est conjugé à/à la Alexa Fluor 555

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FOXO1

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FOXO1

Antigène: FOXO1 (Forkhead Box O1 (FOXO1))

Autre désignation: Foxo1 (FOXO1 Produits)

Synonymes: anticorps FKH1, anticorps FKHR, anticorps FOXO1A, anticorps FoxO1a.1, anticorps foxo1, anticorps zgc:153388, anticorps Fkhr, anticorps Foxo1a, anticorps AI876417, anticorps Afxh, anticorps Fkhr1, anticorps fkh1, anticorps fkhr, anticorps foxo1a, anticorps xFoxO1, anticorps FoxO1A, anticorps foxo1a.2, anticorps forkhead box O1, anticorps forkhead box O1 a, anticorps forkhead box O1 L homeolog, anticorps forkhead box O1 b, anticorps FOXO1, anticorps foxo1a, anticorps Foxo1, anticorps foxo1, anticorps foxo1.L, anticorps foxo1b

Sujet:

Synonyms: FKH1, FKHR, FOXO1A, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1

Background: Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

ID gène: 2308

UniProt: Q12778

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling