FOXO1 anticorps (AA 201-300) (Cy7)

N° du produit ABIN897576

Détail du produit anti-FOXO1 anticorps (Cy7)

Antigène: FOXO1 (Forkhead Box O1 (FOXO1))

Épitope: AA 201-300

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXO1 est conjugé à/à la Cy7

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FOXO1 + FOXO3 + FOXO4

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FOXO1

Antigène: FOXO1 (Forkhead Box O1 (FOXO1))

Autre désignation: FOXO1/3/4 (FOXO1 Produits)

Synonymes: anticorps FKH1, anticorps FKHR, anticorps FOXO1A, anticorps FoxO1a.1, anticorps foxo1, anticorps zgc:153388, anticorps Fkhr, anticorps Foxo1a, anticorps AI876417, anticorps Afxh, anticorps Fkhr1, anticorps fkh1, anticorps fkhr, anticorps foxo1a, anticorps xFoxO1, anticorps FoxO1A, anticorps foxo1a.2, anticorps forkhead box O1, anticorps forkhead box O1 a, anticorps forkhead box O1 L homeolog, anticorps forkhead box O1 b, anticorps FOXO1, anticorps foxo1a, anticorps Foxo1, anticorps foxo1, anticorps foxo1.L, anticorps foxo1b

Sujet:

Synonyms: AFX1, FOXO1+FOXO3+FOXO4, FKH1, FKHRL1, FKHRL1P2, Forkhead box O1, Forkhead box O3, Forkhead box O4, FOXO1, FOXO2, FOXO3, FOXO4, MLLT7, FOXO1_HUMAN.

Background: FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.

ID gène: 2308

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling