TLR4 anticorps
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- Antigène Voir toutes TLR4 Anticorps
- TLR4 (Toll-Like Receptor 4 (TLR4))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TLR4 est non-conjugé
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Application
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Specificité
- Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria. The HTA125 monoclonal antibody reacts preferentially, especially in flow cytometry, with human TLR4 that is associated with MD-2. HTA125 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. The antibody was shown to precipitate TLR4 (100 kD).
- Purification
- Purified
- Immunogène
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Type of Immunogen: Native protein - Clone
- HTA125
- Isotype
- IgG2a
- Top Product
- Discover our top product TLR4 Anticorps primaire
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- Indications d'application
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Approved: Flo, IP
Usage: The antibody can be used for flow cytometry, immuno precipitation and immunohistology on frozen sections. Furthermore the antibody can be used as antagonist for TLR4, it blocks LPS-induced cytokine production. - Commentaires
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, 0.02 % sodium azide, 0.1 % BSA
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 4°C.
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- Antigène
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Autre désignation
- TLR4 (TLR4 Produits)
- Synonymes
- anticorps ARMD10, anticorps CD284, anticorps TLR-4, anticorps TOLL, anticorps Lps, anticorps Ly87, anticorps Ran/M1, anticorps Rasl2-8, anticorps toll like receptor 4, anticorps toll-like receptor 4, anticorps TLR4, anticorps Tlr4
- Sujet
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Name/Gene ID: TLR4
Family: Toll-like Receptor
Synonyms: TLR4, CD284, CD284 antigen, Homolog of Drosophila toll, TLR-4, TOLL, ARMD10, Toll-like receptor 4, HToll - ID gène
- 7099
- UniProt
- O00206
- Pathways
- Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins
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