IKK alpha anticorps (AA 500-590)

N° du produit ABIN965896

Cet anticorps Souris Monoclonal détecte spécifiquement IKK alpha dans WB et ELISA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour IKK alpha anticorps (AA 500-590) (ABIN965896)

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IKK alpha est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 7C10B6-1A10A10

Détail du produit anti-IKK alpha anticorps

Épitope: AA 500-590

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of CHUK (aa500-590) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-IKK alpha (ABIN965896)

Park, Krishnan, OMalley, Yamamoto, Gaynor: "Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation." dans: Molecular cell, Vol. 18, Issue 1, pp. 71-82, (2005) (PubMed).

Prajapati, Verma, Yamamoto, Kwak, Gaynor: "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity." dans: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1739-46, (2004) (PubMed).

Détails sur IKK alpha

Antigène: IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

Autre désignation: CHUK

Sujet: CHUK: conserved helix-loop-helix ubiquitous kinase. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
Synonyms: IKK1, IKKA, IKBKA

ID gène: 1147

Pathways: Signalisation PI3K-Akt, Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins