SHC1 anticorps (AA 359-473)
-
- Antigène Voir toutes SHC1 Anticorps
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
-
Épitope
- AA 359-473
-
Reactivité
- Humain, Souris, Rat, Chien, Poulet
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp SHC1 est non-conjugé
-
Application
- Western Blotting (WB), Immunofluorescence (IF)
- Réactivité croisée
- Souris, Rat (Rattus), Chien, Poulet
- Attributs du produit
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human SHC aa. 359-473
- Clone
- 30-SHC
- Isotype
- IgG1
- Top Product
- Discover our top product SHC1 Anticorps primaire
-
-
- Commentaires
-
Related Products: ABIN968535, ABIN967389
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20°C.
-
-
RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death." dans: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22581-9, (2002) (PubMed).
: "Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling." dans: Molecular and cellular biology, Vol. 22, Issue 7, pp. 2375-87, (2002) (PubMed).
: "Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor." dans: The Journal of biological chemistry, Vol. 275, Issue 43, pp. 33321-8, (2000) (PubMed).
: "Integrin activation and focal complex formation in cardiac hypertrophy." dans: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35624-30, (2000) (PubMed).
: "A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction." dans: Cell, Vol. 70, Issue 1, pp. 93-104, (1992) (PubMed).
: "
-
RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death." dans: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22581-9, (2002) (PubMed).
-
- Antigène
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- Autre désignation
- SHC (SHC1 Produits)
- Synonymes
- anticorps SHC1, anticorps SHC, anticorps SHCA, anticorps P66shc, anticorps si:dkey-246i14.4, anticorps wu:fc10h03, anticorps shc, anticorps p66shc, anticorps Shc, anticorps ShcA, anticorps p66, anticorps SHC adaptor protein 1, anticorps Shc1p, anticorps squalene--hopene cyclase, anticorps SHC (Src homology 2 domain containing) transforming protein 1, anticorps SHC (Src homology 2 domain containing) transforming protein 1 L homeolog, anticorps src homology 2 domain-containing transforming protein C1, anticorps SHC1, anticorps shc1, anticorps Shc1, anticorps shc1.L
- Sujet
- The mammalian SHC proteins, which are expressed as multiple isoforms (46, 52, and 66 kDa), each contain a C-terminal SH2 domain and an N-terminal glycine/proline rich sequence. These proteins function as early signaling intermediates (also called adaptor proteins) which relay G protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK)-induced signals via the Ras transduction pathway. To this end, the SHC proteins contain specific tyrosine residues which are phosphorylated following association with the active RTKs. Phosphorylated SHC forms a complex with the adaptor protein GRB2. Association of the SHC-GRB2 complex with the Ras guanine nucleotide exchange factor (Ras-GEF) mediates the localization of Ras-GEF to the plasma membrane. Once at the plasma membrane, Ras-GEF activates Ras by catalyzing the Ras-GTP for Ras-GDP exchange. Over-expression of SHC results in cell transformation, and phosphorylation of SHC correlates with activation of the ERK1/ERK2 kinases. The SHC proteins are mediators of signals that are essential for cell metabolism, growth, and differentiation.
- Poids moléculaire
- 66, 52 & 46 kDa
- Pathways
- Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
-