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Data indicate that Insl6 is an injury-regulated myokine that functions as a myogenic regenerative factor.
The presence of immunoreactive INSL6 in discrete populations of hypothalamic and brainstem neurons and in Leydig cells of the testis suggests a diverse biological function of this novel peptide.
results suggest that INSL6 modulates two different processes related to fertility, spermatogenesis, and sperm motility.
Insl6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization.
insulin-like peptide 5
, insulin-like peptide 6
, insulin-like peptide INSL6
, relaxin/insulin-like factor 1