IL1RN Protein (AA 26-177)

N° du produit ABIN2667496

Détail du produit

Antigène: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 26-177

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Flow Cytometry (FACS)

Pureté: >98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.

niveau d'endotoxine:

Less than 0.1 ng per μg of protein.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Biological activity: ED50 is 20 - 40 ng/ml in the presence of 50 pg/ml of IL-1α, corresponding to a specific activity of 2.5 - 5.0 x 105 units/mg as determined by its ability to inhibit the IL-1α stimulation of murine D10S cell.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer, such as 5 % Trehalose, and store working aliquots at -20 °C to -80 °C.

Buffer: Lyophilized, carrier-free.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Unopened vial can be stored at -20°C or -70°C.

Détail du antigène

Antigène: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Autre désignation: IL-1RA (IL1RN Produits)

Synonymes: DIRA Protein, ICIL-1RA Protein, IL-1RN Protein, IL-1ra Protein, IL-1ra3 Protein, IL1F3 Protein, IL1RA Protein, IRAP Protein, MVCD4 Protein, IRAP1 Protein, IL1RN Protein, IL-1RA Protein, F630041P17Rik Protein, interleukin 1 receptor antagonist Protein, interleukin 1 receptor antagonist-like Protein, IL1RN Protein, Il1rn Protein, IL1RNL Protein

Sujet: Interleukin-1 receptor antagonist (IL-1RA or IL-RN) is a member of IL-1 family cytokine and it is a naturally occurring inflammatory inhibitor protein. It competes with IL-1α and IL-1β for binding to type I and type II receptors. It can modulate a variety of interleukin 1 related immune and inflammatory responses. IL-1RA has been shown to block the inflammatory responses induced by IL-1 both in vitro and in vivo model. Recombinant IL-1RA (anakinra) has been used as to treat rheumatoid arthritis. A polymorphism of IL-1RN gene is reported to be associated with increased risk of osteoporotic fractures, gastric cancer, bladder cancer, and other cancer types.

Poids moléculaire: The 153 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of 17.2 kDa. The predicted N-terminal amino acid is Met.

Pathways: Signalisation NF-kappaB, Hormone Transport, Cancer Immune Checkpoints