Bcl-2 Protein (AA 1-210) (His tag)

N° du produit ABIN620234

Détail du produit

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Type de proteíne: Recombinant

Attributs du protein: AA 1-210

Origine: Humain

Hôte: Veuillez nous consulter SVP

Purification/Conjugué: Cette Bcl-2 protéine est marqué à la His tag.

Attributs du produit: Recombinant Human B-Cell Leukemia/Lymphoma 2, His6-tagged

Pureté: > 95.0 % as determined by SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: The protein contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl.Suspend BclXL in 100ul of 0.5M Acetic acid, over night at 4°C. Dilute 10 fold into selected buffer system. Bcl-XL has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended.

Stock: -20 °C

Détail du antigène

Antigène: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Autre désignation: B-Cell Leukemia/Lymphoma 2 (BCL2 Produits)

Synonymes: Bcl-2 Protein, PPP1R50 Protein, bcl-2 Protein, AW986256 Protein, C430015F12Rik Protein, D630044D05Rik Protein, D830018M01Rik Protein, BCL-2 Protein, Bcl2 Protein, BCL2, apoptosis regulator Protein, B cell leukemia/lymphoma 2 Protein, B-cell CLL/lymphoma 2a Protein, B-cell CLL/lymphoma 2 protein Protein, BCL2 Protein, Bcl2 Protein, bcl2a Protein, BCL-2 Protein

Sujet: Bcl-XL Human Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing AA 1-210. The Bcl-XL is expressed as His-Tag fusion protein and purified by proprietary chromatographic techniques. Introduction: Bcl-XL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays arole in the signal transduction pathway of the FAS-Ligand. Bcl-XL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. BCL-XL is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. Bcl-xL has cell death repressor activity and therefore acts as a survival protein. Synonyms: BclXL, Bcl-X(L), Bcl-XL.

Pathways: Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling