IL-5 Protein (AA 20-134) (His tag)
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- Antigène Voir toutes IL-5 (IL5) Protéines
- IL-5 (IL5) (Interleukin 5 (IL5))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 20-134
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette IL-5 protéine est marqué à la His tag.
- Pureté
- >90 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL5 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -20 °C
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- Antigène
- IL-5 (IL5) (Interleukin 5 (IL5))
- Autre désignation
- IL-5 (IL5 Produits)
- Synonymes
- EDF Protein, IL-5 Protein, TRF Protein, Il-5 Protein, IL5 Protein, interleukin 5 Protein, IL5 Protein, Il5 Protein
- Sujet
- Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.
- Poids moléculaire
- 15.0 kDa
- NCBI Accession
- NP_000870
- Pathways
- Signalistation JAK/STAT, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Feeding Behaviour
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