GPC2 Protein (AA 24-553) (Fc Tag)
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- Antigène Voir toutes GPC2 Protéines
- GPC2 (Glypican 2 (GPC2))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 24-553
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette GPC2 protéine est marqué à la Fc Tag.
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product GPC2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Stock
- -20 °C
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- Antigène
- GPC2 (Glypican 2 (GPC2))
- Autre désignation
- Glypican 2 (GPC2 Produits)
- Synonymes
- 2410016G05Rik Protein, glypican 2 Protein, glypican 2 (cerebroglycan) Protein, GPC2 Protein, Gpc2 Protein
- Sujet
- Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
- Poids moléculaire
- 37.3 kDa & 47.3 kDa
- NCBI Accession
- NP_689955
- Pathways
- Glycosaminoglycan Metabolic Process
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