HRAS Protein (His tag)

N° du produit ABIN7196121

Détail du produit

Antigène: HRAS (HRas proto-oncogene, GTPase (HRAS))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette HRAS protéine est marqué à la His tag.

Fonction: Recombinant Human HRAS/GTPase Hras Protein (His Tag)

Séquence: Met 1-Cys 186

Attributs du produit: A DNA sequence encoding the human HRAS (P01112) (Met 1-Cys 186) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 94 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: HRAS (HRas proto-oncogene, GTPase (HRAS))

Autre désignation: HRAS/GTPase Hras (HRAS Produits)

Synonymes: C-BAS/HAS Protein, C-H-RAS Protein, C-HA-RAS1 Protein, CTLO Protein, H-RASIDX Protein, HAMSV Protein, HRAS1 Protein, K-RAS Protein, N-RAS Protein, RASH1 Protein, hras Protein, zgc:110250 Protein, HRAS Protein, H-RAS Protein, c-H-ras Protein, H-Ras Protein, K-Ras Protein, hras1 Protein, rash1 Protein, ras Protein, N-Ras Protein, c-bas/has Protein, H-ras Protein, Ha-ras Protein, Harvey-ras Protein, Hras-1 Protein, Kras2 Protein, c-Ha-ras Protein, c-rasHa Protein, hrasl Protein, zgc:110734 Protein, HRas proto-oncogene, GTPase Protein, v-Ha-ras Harvey rat sarcoma viral oncogene homolog a Protein, neuroblastoma RAS viral (v-ras) oncogene homolog pseudogene Protein, Harvey rat sarcoma viral oncogene homolog L homeolog Protein, Harvey rat sarcoma viral oncogene homolog Protein, Harvey rat sarcoma virus oncogene Protein, NRAS proto-oncogene, GTPase Protein, -Ha-ras Harvey rat sarcoma viral oncogene homolog b Protein, HRAS Protein, hrasa Protein, LOC733587 Protein, Hras Protein, hras.L Protein, hras Protein, NRAS Protein, hrasb Protein

Sujet:

Background: HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is arare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities, tumor predisposition, skin and musculoskeletal abnormalities. Defects in HRAS also can cause congenital myopathy with excess of muscle spindles. HRAS deficiency may be a cause of susceptibility to Hurthle cell thyroid carcinoma. It has been shown that defects in HRAS can cause susceptibility to bladder cancer which is a malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas. They begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences. Defects in HRAS are the cause of oral squamous cell carcinoma.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: C-BAS/HAS;C-H-RAS;C-HA-RAS1;CTLO;H-RASIDX;HAMSV;HRAS1;p21ras;RASH1

Poids moléculaire: 22.4 kDa

UniProt: P01112

Pathways: Signalisation p53, Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling, BCR Signaling