SHP1 Protein (AA 207-597) (GST tag,His tag)

N° du produit ABIN7320120

Détail du produit

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 207-597

Origine: Souris

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette SHP1 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Mouse PTPN6/SH-PTP1 Protein (aa 207-597, His & GST Tag)(Active)

Séquence: Ala207-Lys597

Attributs du produit: A DNA sequence encoding the mouse PTPN6 (P29351-2) (Ala207-Lys597) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 85 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 4 μmoles/min/μg.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.0, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Autre désignation: PTPN6/SH-PTP1 (PTPN6 Produits)

Synonymes: HCPH Protein, HPTP1C Protein, PTP-1C Protein, SH-PTP1 Protein, SHP-1 Protein, SHP-1L Protein, SHP1 Protein, DRPLA Protein, Hcph Protein, Ptp1C Protein, me Protein, motheaten Protein, Ptph6 Protein, Shp-1 Protein, fj22f05 Protein, wu:fj22f05 Protein, zgc:55501 Protein, ptpn6 Protein, protein tyrosine phosphatase, non-receptor type 6 Protein, protein tyrosine phosphatase, non-receptor type 6 L homeolog Protein, PTPN6 Protein, Ptpn6 Protein, ptpn6 Protein, ptpn6.L Protein

Sujet:

Background: PTPN6 is an enzyme which belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. It has been shown that PTPN6 interacts with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.

Synonym: 70Z-SHP,hcp,Hcph,me,Ptp1C,PTPTY-42,SH-PTP1,SHP-1

Poids moléculaire: 72.7 kDa

Pathways: Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling