SHP1 Protein (His tag)

N° du produit ABIN7318965

Détail du produit

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SHP1 protéine est marqué à la His tag.

Fonction: Recombinant Human PTPN6/SH-PTP1 Protein (His Tag)

Séquence: Lys243-Ile541

Attributs du produit: Recombinant Human Protein-Tyrosine Phosphatase 1C is produced by our E.coli expression system and the target gene encoding Lys243-Ile541 is expressed with a 6His tag at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 25 mM TrisHCl, 2 mM β-ME, 1 mM EDTA, 1 mM DTT, 20 % Glycerol, pH 7.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Autre désignation: PTPN6/SH-PTP1 (PTPN6 Produits)

Synonymes: HCPH Protein, HPTP1C Protein, PTP-1C Protein, SH-PTP1 Protein, SHP-1 Protein, SHP-1L Protein, SHP1 Protein, DRPLA Protein, Hcph Protein, Ptp1C Protein, me Protein, motheaten Protein, Ptph6 Protein, Shp-1 Protein, fj22f05 Protein, wu:fj22f05 Protein, zgc:55501 Protein, ptpn6 Protein, protein tyrosine phosphatase, non-receptor type 6 Protein, protein tyrosine phosphatase, non-receptor type 6 L homeolog Protein, PTPN6 Protein, Ptpn6 Protein, ptpn6 Protein, ptpn6.L Protein

Sujet:

Background: Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. In addition, PTP1C also modulates signaling by tyrosine phosphorylated cell surface receptors.

Synonym: Tyrosine-Protein Phosphatase Non-Receptor Type 6, Hematopoietic Cell Protein-Tyrosine Phosphatase, Protein-Tyrosine Phosphatase 1C, PTP-1C, Protein-Tyrosine Phosphatase SHP-1, SH-PTP1, PTPN6, HCP, PTP1C

Poids moléculaire: 35.4 kDa

Pathways: Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling