MASP2 Protein (AA 287-685) (His tag,Biotin)
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- Antigène Voir toutes MASP2 Protéines
- MASP2 (Mannan-Binding Lectin serine Peptidase 2 (MASP2))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 287-685
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Origine
- Rat
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette MASP2 protéine est marqué à la His tag,Biotin.
- Fonction
- Biotinylated Rat MASP2 Protein (Primary Amine Labeling)
- Séquence
- Thr287-Phe685
- Attributs du produit
- Recombinant Biotinylated Rat MASP2 Protein (Primary Amine Labeling) is expressed from E.coli with His tag at the C-Terminus.It contains Thr287-Phe685.
- Pureté
- > 95 % as determined by Tris-Bis PAGE
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Anti-MASP2 Antibody, hFc Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Rat MASP2, His Tag with the EC50 of 19.3ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product MASP2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied as 0.22μm filtered solution in 50 mM Tris, 200 mM NaCl ( pH 9.0).
- Stock
- -80 °C
- Stockage commentaire
- Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- MASP2 (Mannan-Binding Lectin serine Peptidase 2 (MASP2))
- Autre désignation
- MASP2 (MASP2 Produits)
- Synonymes
- MAP19 Protein, MASP-2 Protein, MASP1P1 Protein, sMAP Protein, MAp19 Protein, mannan binding lectin serine peptidase 2 Protein, mannan-binding lectin serine peptidase 2 Protein, MASP2 Protein, Masp2 Protein
- Sujet
- The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is observed with the middle east respiratory syndrome (MERS), severe acquired respiratory syndrome (SARS), and SARS-CoV-2. Activation of the lectin pathway via mannose-binding lectin associated serine protease 2 (MASP2) is witnessed under discrete viral infections including COVID-19.
- Poids moléculaire
- 46.7 kDa. Due to autocatalytic cleavage, the protein migrates to 15-20 kDa&25-30 kDa based on Tris-Bis PAGE result.
- UniProt
- A2VCV7
- Pathways
- Système du Complément
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