GTPase NRas Protein (NRAS) (AA 1-186) (His tag)

N° du produit ABIN7504485

Détail du produit

Antigène: GTPase NRas (NRAS)

Type de proteíne: Recombinant

Attributs du protein: AA 1-186

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette GTPase NRas protéine est marqué à la His tag.

Fonction: Human NRAS Protein

Séquence: Met1-Cys186

Attributs du produit: Recombinant Human NRAS Protein is expressed from E.coli with His tag at the N-Terminus.It contains Met1-Cys186.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: GTPase NRas (NRAS)

Autre désignation: NRAS (NRAS Produits)

Synonymes: NRAS Protein, AV095280 Protein, N-ras Protein, ALPS4 Protein, NRAS1 Protein, NS6 Protein, N-RAS Protein, fj99a10 Protein, wu:fj99a10 Protein, zgc:100761 Protein, zras-b1 Protein, H-RAS Protein, HRAS Protein, GTPase NRas Protein, neuroblastoma RAS viral (v-ras) oncogene homolog L homeolog Protein, NRAS proto-oncogene, GTPase Protein, neuroblastoma ras oncogene Protein, neuroblastoma RAS viral oncogene homolog Protein, Tsp_01117 Protein, nras.L Protein, Nras Protein, NRAS Protein, nras Protein

Sujet: NRas is a key mediator of the mitogenic pathway in normal cells and in cancer cells. Its dynamics and nanoscale organization at the plasma membrane (PM) facilitate its signaling. NRas activity is mediated and regulated by its dynamic interactions with functional (Grb2, BRAF, NF1, and GPI-nucleated) clusters at the PM.

Poids moléculaire: 22.29 kDa same as Tris-Bis PAGE result.

UniProt: P01111

Pathways: Signalisation p53, Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling