CDC42 Protein (AA 1-188) (His tag)

N° du produit ABIN7505004

Détail du produit

Antigène: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Type de proteíne: Recombinant

Attributs du protein: AA 1-188

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CDC42 protéine est marqué à la His tag.

Séquence: Met1-Cys188

Attributs du produit: A DNA sequence encoding theHuman CDC42 protein (P60953-2) (Met1-Cys188) was expressed with a N-His.

Pureté: >95 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42))

Autre désignation: CDC42 (CDC42 Produits)

Synonymes: CDC42Hs Protein, G25K Protein, AI747189 Protein, AU018915 Protein, cdc42a Protein, wu:fb07d08 Protein, wu:fj62g06 Protein, zgc:63918 Protein, Xcdc42 Protein, cdc42hs Protein, g25k Protein, CDC42 Protein, CG12530 Protein, Cdc42Dm Protein, D-CDC42 Protein, D-Cdc42 Protein, D-cdc42 Protein, DCDC42 Protein, DCdc42 Protein, Dcdc42 Protein, Dm Cdc42 Protein, DmCDC42 Protein, Dmcdc42 Protein, Dmel\\CG12530 Protein, cdc42 Protein, cell division cycle 42 Protein, Cell division control protein 42 homolog Protein, cell division control protein 42 homolog Protein, cell division cycle 42 L homeolog Protein, CG12530 gene product from transcript CG12530-RC Protein, Rho family GTPase Protein, CDC42 Protein, Cdc42 Protein, cdc42 Protein, LOC100636735 Protein, LOC100637699 Protein, LOC100638834 Protein, cdc42.L Protein

Sujet:

Background: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase.Regulates cell migration.In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections.Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation.Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling.Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.

Synonym: G25K GTP-binding protein

Poids moléculaire: 20.9 kDa

Pathways: Signalisation MAPK, Dynamique des Microtubules, Signalisation RTK, Signalisation WNT, TCR Signaling, EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2, EGFR Downregulation, VEGF Signaling