Aperçu des produits pour anti-PML-RARA Regulated Adaptor Molecule 1 (PRAM1) Anticorps

Mouse (Murine) PML-RARA Regulated Adaptor Molecule 1 (PRAM1) interaction partners

1. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1/SKAP-HOM and SLP-76/Vav/PLCgamma2 signaling hubs may be critical for Yersinia survival.

2. autophagy contributes to the anti-apoptotic function of the PML-RARalpha protein through inhibiting the Akt/mTOR pathway

3. Transgenic mice expressing PML-RAR alpha develop acute promyelocytic leukemia with long latency, low penetrance, and acquired cytogenetic abnormalities.

Human PML-RARA Regulated Adaptor Molecule 1 (PRAM1) interaction partners

1. we diagnosed a spinal promyelocytic sarcoma as a manifestation of acute promyelocytic leukaemia with M3 morphology according to the French-American-British classification with t(15;17)(q22;q21) and PML-RARA fusion gene

2. This study establishes PML as an important regulator of NF-kappaB and demonstrates that PML-RARalpha dysregulates NF-kappaB.

3. Our results show that the pretreatment PML-RARA molecular burden could therefore be used to improve risk stratification in order to develop more individualized treatment regimens for high-risk APL cases.

4. The 3-plex RT-qPCR assay is a specific, sensitive, stable, and cost-effective method that can be used for the rapid diagnosis and treatment monitoring of acute promyelocytic leukemia with PML-RARa

5. The MIR125B1-mediated blockade of PML-RARA proteolysis was regulated via an autophagy-lysosomal pathway, contributing to the inhibition of acute promyelocytic leukemia differentiation.

6. autophagy contributes to the anti-apoptotic function of the PML-RARalpha protein through inhibiting the Akt/mTOR pathway

7. PRAM-1 is required for optimal integrin-dependent neutrophil function.

8. Caspase 3-cleaved SH3 domain of HIP-55 is likely involved in PRAM-1-mediated JNK activation upon arsenic trioxide-induced differentiation of NB4 cells.

9. The use of reverse-transcription polymerase chain reaction for the detection of the PML-RARA and RARA-PML fusion genes that allow for monitoring of acute myelocytic leukemia.

10. PML-RARalpha fusion transcripts have been shown to be useful markers for establishing the diagnosis and for monitoring the response to treatment of acute promyelocytic leukemia.

11. Interaction of PRAM-1 and hSH3 domains of adhesion and degranulation promoting adapter protein (ADAP) with phosphatidylcholine-containing liposomes is observed upon incorporation of phosphatidylserine or phosphoinositides into the membrane bilayer.

12. hidden abnormalities and novel disease-related genomic changes occur in t(15;17)translocation in acute promyelocytic leukemia formation of PML-RARA gene

13. We conclude that our sp-RQ-PCR is specific enough to identify various forms of PML-RARalpha and yields no false-positive results.