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anti-Human RPS6KA1 Anticorps:
anti-Mouse (Murine) RPS6KA1 Anticorps:
anti-Rat (Rattus) RPS6KA1 Anticorps:
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Chicken Monoclonal RPS6KA1 Primary Antibody pour IF, IP - ABIN967837
Chung, Pelech, Blenis: Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity. dans Proceedings of the National Academy of Sciences of the United States of America 1991
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Chicken Monoclonal RPS6KA1 Primary Antibody pour IF, IP - ABIN967838
Hsiao, Chou, Shih, Ferrell: Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo. dans Proceedings of the National Academy of Sciences of the United States of America 1994
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Human Polyclonal RPS6KA1 Primary Antibody pour DB, WB - ABIN1881765
Roux, Ballif, Anjum, Gygi, Blenis: Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. dans Proceedings of the National Academy of Sciences of the United States of America 2004
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Polyclonal RPS6KA1 Primary Antibody pour WB - ABIN4948290
Eisenmann, VanBrocklin, Staffend, Kitchen, Koo: Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad. dans Cancer research 2003
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Human Polyclonal RPS6KA1 Primary Antibody pour ELISA, WB - ABIN1043905
Chaturvedi, Poppleton, Stringfield, Barbier, Patel: Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase. dans Molecular and cellular biology 2006
These results suggest that RSK1 protects P-gp (Montrer ABCB4 Anticorps) against ubiquitination by reducing UBE2R1 (Montrer CDC34 Anticorps) stability.
Data suggest that UBR5 (Montrer UBR5 Anticorps) down-regulates levels of TRAF3 (Montrer TRAF3 Anticorps), a key component of Toll (Montrer TLR4 Anticorps)-like receptor signaling, via the miRNA pathway; p90RSK is an upstream regulator of UBR5 (Montrer UBR5 Anticorps); p90RSK phosphorylates UBR5 (Montrer UBR5 Anticorps) as required for translational repression of TRAF3 (Montrer TRAF3 Anticorps) mRNA. (UBR5 (Montrer UBR5 Anticorps) = ubiquitin protein ligase E3 component n-recognin 5 (Montrer UBR5 Anticorps) protein; TRAF3 (Montrer TRAF3 Anticorps) = TNF receptor-associated factor 3 (Montrer TRAF3 Anticorps); p90RSK = 90 kDa ribosomal protein S6 (Montrer RPS6 Anticorps) kinase (Montrer RPS6KB1 Anticorps))
Data indicate that BTG2 (Montrer BTG2 Anticorps), MAP3K11 (Montrer MAP3K11 Anticorps), RPS6KA1 and PRDM1 (Montrer PRDM1 Anticorps) as putative targets of microRNA miR (Montrer MLXIP Anticorps)-125b.
VEGF-A (Montrer VEGFA Anticorps) driven Mdm2 (Montrer MDM2 Anticorps) phosphorylation on Ser166 is dependent on the ERK1/2 (Montrer MAPK1/3 Anticorps)/p90RSK signaling pathway in primary human endothelial cells.
The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID (Montrer BID Anticorps) may serve as an alternative cancer treatment in NSCLC.
RSK1 binds to EBP50 (Montrer SLC9A3R1 Anticorps) at its first PDZ domain (Montrer INADL Anticorps), and mitogen activated RSK1 phosphorylates EBP50 (Montrer SLC9A3R1 Anticorps) at T156, an event that is crucial for its nuclear localization
Data show that the 90 kDa ribosomal protein S6 (Montrer RPS6 Anticorps) kinases RSK1 and RSK2 (Montrer RPS6KA3 Anticorps) play a key role in the homing of ovarian cancer cells in metastatic sites by regulating cell adhesion and invasion.
RSK1 and 3 but not RSK2 (Montrer RPS6KA3 Anticorps) are down-regulated in breast tumour and are associated with disease progression. RSK may be a key component in the progression and metastasis of breast cancer.
PKD2 (Montrer PKD2 Anticorps) and RSK1 regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.
Results indicate that the phosphorylation of EphA2 (Montrer EPHA2 Anticorps) at Ser (Montrer SIGLEC1 Anticorps)-897 is controlled by RSK and the RSK-EphA2 (Montrer EPHA2 Anticorps) axis might contribute to cell motility and promote tumour malignant progression.
In hippocampal neurons of wild-type mice, pP90RSK translocates into the nucleus upon stimulation with forskolin (left), whereas in Period1-knockout (Per1 (Montrer PER1 Anticorps)(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
Data show that the phosphoinositide-dependent kinase 1 (PDK1 (Montrer PDPK1 Anticorps))-p90 (Montrer GPAM Anticorps) kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.
IL-6 (Montrer IL6 Anticorps) induces the activation of the Stat3 (Montrer STAT3 Anticorps) signaling and promotes the downmodulation of the p90RSK/eEF2 (Montrer EEF2 Anticorps) and mTOR (Montrer FRAP1 Anticorps)/p70S6K (Montrer RPS6KB1 Anticorps) axes, while it does not affect the activation of AKT (Montrer AKT1 Anticorps).
analysis of p38 (Montrer CRK Anticorps)-MK2 (Montrer KCNA2 Anticorps)-activated Rsk signaling in toll (Montrer TLR4 Anticorps)-like receptor-stimulated dendritic cells
These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK (Montrer EPHB2 Anticorps), which for quetiapine occurs via an EGFR (Montrer EGFR Anticorps)-linked mechanism, possibly indicating involvement of this system in its action.
hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 (Montrer SLC9A1 Anticorps) induces cardiomyocyte apoptosis.
RSK1 Cys223 glutathionylation may contribute to regulate the levels of nitric in the brain.
Our study highlights the importance of the p90RSK/ERK5 (Montrer MAPK7 Anticorps) module as a critical mediator of endothelial dysfunction in diabetes mellitus and atherosclerosis formation.
Results show increased protein levels of Rsk1 and Rsk2 (Montrer RPS6KA3 Anticorps) in the striatum of Huntington disease (Montrer HTT Anticorps) mice and and striatal cells transfected with full-length mutant Huntingtin (Montrer HTT Anticorps).
Type I keratin (Montrer KRT12 Anticorps) 17 (Montrer KRT17 Anticorps) protein is phosphorylated on serine 44 by p90 (Montrer GPAM Anticorps) ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
90 kDa ribosomal protein S6 kinase 1
, MAP kinase-activated protein kinase 1a
, MAPK-activated protein kinase 1a
, MAPKAP kinase 1a
, S6K-alpha 1
, dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
, p90-RSK 1
, ribosomal S6 kinase 1
, ribosomal protein S6 kinase alpha 1
, ribosomal protein S6 kinase alpha-1
, ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1
, MAP kinase-activated protein kinase 1
, MAPK-activated protein kinase 1
, MAPKAP kinase 1
, ribosomal protein S6 kinase 2 alpha
, ribosomal protein S6 kinase II alpha
, S6 protein kinase (Rsk-1)
, S6 kinase II beta
, ribosomal protein S6 kinase 2 beta
, ribosomal protein S6 kinase II beta
, ribosomal protein S6 kinase a, polypeptide 1