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anti-Human Insulin Anticorps:
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Buffalo (Bubalus) Polyclonal Insulin Primary Antibody pour IEM, ICC - ABIN617877
Tay, Wong: Insulin-like immunoreactivity in the monkey spinal cord. dans Acta anatomica 1992
Show all 44 Pubmed References
Human Monoclonal Insulin Primary Antibody pour IHC (p) - ABIN3043651
Han, Qiu, Zhang, Kong, Wang, Wang, Li, Duan, Wang, Song, Wang: Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats. dans Experimental biology and medicine (Maywood, N.J.) 2009
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Cow (Bovine) Monoclonal Insulin Primary Antibody pour CyTOF, FACS - ABIN4900790
Cucak, Grunnet, Rosendahl: Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. dans Journal of leukocyte biology 2014
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Cow (Bovine) Monoclonal Insulin Primary Antibody pour FACS - ABIN4898619
Kalis, Bolmeson, Esguerra, Gupta, Edlund, Tormo-Badia, Speidel, Holmberg, Mayans, Khoo, Wendt, Eliasson, Cilio: Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. dans PLoS ONE 2012
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Human Polyclonal Insulin Primary Antibody pour EIA, FACS - ABIN372838
Madsen, Knauf, Gotfredsen, Pilling, Sjögren, Andersen, Andersen, de Boer, Manova, Barlas, Vundavalli, Nyborg, Knudsen, Moelck, Fagin: GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation. dans Endocrinology 2012
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Human Polyclonal Insulin Primary Antibody pour IHC, IHC (p) - ABIN4326017
Lindskog, Asplund, Engkvist, Uhlen, Korsgren, Ponten: Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets. dans Discovery medicine 2010
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Pig (Porcine) Polyclonal Insulin Primary Antibody pour IF, IHC - ABIN926149
Johansson, Rasmusson, Niclou, Forslund, Gustavsson, Nilsson, Korsgren, Magnusson: Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization. dans Diabetes 2008
Human Monoclonal Insulin Primary Antibody pour IF (p) - ABIN722608
Zöllner, Jouni, Panzer, Khadour, Janzen, Wesche, Ten Berg, Schellong, Heinken, Greinacher, Bakchoul: Platelet activation in the presence of neutral protamine Hagedorn insulin: a new feature of antibodies against protamine/heparin complexes. dans Journal of thrombosis and haemostasis : JTH 2016
Cow (Bovine) Monoclonal Insulin Primary Antibody pour ELISA - ABIN2475102
Oran, Jarvis, Borges, Sherma, Nelson: Mass spectrometric immunoassay of intact insulin and related variants for population proteomics studies. dans Proteomics. Clinical applications 2011
Mouse (Murine) Polyclonal Insulin Primary Antibody pour IHC (fro), IHC (p) - ABIN2475101
Ortsäter, Grankvist, Wolfram, Kuehn, Sjöholm: Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. dans Nutrition & metabolism 2012
genetic association studies in population of children in Japan: Data suggest that mutations in INS, HNF1A (Montrer HNF1A Anticorps), HNF4A (Montrer HNF4A Anticorps), and HNF1B (Montrer HNF1B Anticorps) likely play critical roles in children with insulin-requiring autoantibody-negative type 1 diabetes in the population studied. (INS = insulin; HNF1A (Montrer HNF1A Anticorps) = HNF1 homeobox A (Montrer HNF1A Anticorps); HNF4A (Montrer HNF4A Anticorps) = hepatocyte nuclear factor 4 alpha (Montrer HNF4A Anticorps); HNF1B (Montrer HNF1B Anticorps) = HNF1 homeobox B (Montrer HNF1B Anticorps))
Insulin signaling pathway protects neuronal cell lines by Sirt3 (Montrer SIRT3 Anticorps) mediated IRS2 (Montrer IRS2 Anticorps) activation.
Insulin promotes progression of colon cancer by upregulation of ACAT1 (Montrer ACAT1 Anticorps).
Data suggest that serum leptin (Montrer LEP Anticorps) and insulin levels are associated with retinal microvasculature parameters in healthy children and adolescents; higher cardiometabolic risk factors (high serum leptin (Montrer LEP Anticorps), insulin, and insulin resistance) correlate with wider retinal arterioles.
Data, including studies involving single-cell analysis, suggest that insulin-secreting cells exhibit 3 major states regarding unfolded protein response (UPR): (1) low UPR and low insulin gene expression; (2) low UPR and high insulin gene expression; (3) high UPR and low insulin gene expression. The latter state promotes cell proliferation; UPR appears to mediate recovery from ER stress due to high insulin production.
Data confirm that cord blood levels of ghrelin (Montrer GHRL Anticorps), leptin (Montrer LEP Anticorps), and insulin of term newborns correlate with anthropometric parameters at birth (birth weight, head circumference, etc.).
Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A (Montrer STX1A Anticorps) and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein (Montrer PVALB Anticorps) secretagogin (Montrer SCGN Anticorps), which dissociates from tomosyn1 in response to Ca(2 (Montrer CA2 Anticorps)+)-raising stimuli and is required for insulin granule trafficking and exocytosis downstream of Ca(2 (Montrer CA2 Anticorps)+) influx.
results indicate that higher cerebrospinal fluid insulin levels are related to impairment in cognitive performance and biomarkers of Alzheimer's disease among women and non-carriers of the APOE (Montrer APOE Anticorps) varepsilon4 allele
single-particle cryo-electron microscopy reconstructions of the 1:2 (4.3 A) and 1:1 (7.4 A) complexes of the insulin receptor (Montrer INSR Anticorps) ECD (Montrer SHFM1 Anticorps) dimer with insulin
Data suggest that higher plasma levels of ceramide with saturated fatty acid are associated with higher fasting levels of insulin and insulin resistance; in contrast, higher levels of sphingomyelin with saturated fatty acid are associated with lower fasting insulin and insulin resistance; this study was conduced in American Indians in AZ, OK, SD, and ND.
Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (Montrer ATP1A1 Anticorps) activity and SFK signaling.
PTPLAD1 (Montrer PTPLAD1 Anticorps) and AMPK (Montrer PRKAA1 Anticorps) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (Montrer ATIC Anticorps) later accumulates in the Golgi/endosome fraction.
Pdx-1 (Montrer PDX1 Anticorps), MafA (Montrer MAFA Anticorps) and NeuroD1 (Montrer NEUROD1 Anticorps) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.
The interplay of the adiponectin system, TNFalpha (Montrer TNF Anticorps) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (Montrer PPARG Anticorps), as well as on the activation of main insulin signaling pathways, is reported.
Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.
Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.
Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.
The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (Montrer IGF1 Anticorps) levels are less easily modified.
insulin increased GCLc (Montrer GCLC Anticorps) promoter activity, which required a prerequisite increase or decrease in medium glucose
The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer.
Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period
Differences between human and bovine insulin kinetics under shear
increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (Montrer LEP Anticorps)-NPY (Montrer NPY Anticorps) and insulin signaling pathways.
Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.
Contains Binding kinetics for insulin binding
Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (Montrer VMP1 Anticorps)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.
The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (Montrer FRAP1 Anticorps) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.
insulin supports early initiation of the mesodermal factor Brachyury (Montrer TBX1 Anticorps) and the signalling molecules Wnt3a (Montrer WNT3A Anticorps) and Wnt4 (Montrer WNT4 Anticorps) as well as the progression of mesoderm formation
Data show that type 1 diabetic blastocyst did not express insulin mRNA.
High INS2 expression is associated with weight gain and obesity.
Data (including data from studies in knockout mice) suggest that Ins2 is involved in impaired nociception/diabetic neuropathy; here, mice heterozygous for mutant Ins2 exhibit (a) significant loss of intra-epidermal nerve fibers, (b) markedly reduced responsiveness to heat in dorsal root ganglion neurons, and (c) mostly unchanged function of cold-sensitive neurons; such mice become diabetic soon after weaning.
In the present study, the mRNA expression of the two mouse insulin genes Ins1 and Ins2 was investigated in MIN6 cells treated with different concentrations of melatonin, and insulin secretion was detected under the same conditions. Following the overexpression or silencing of MTNR1B (Montrer MTNR1B Anticorps), the activities of components of the MAPK (Montrer MAPK1 Anticorps) signaling pathway
These results suggest that PABP (Montrer EBP Anticorps) interacts with HuD (Montrer ELAVL4 Anticorps) in basal glucose conditions making translation inhibitory complex, however upon glucose stimulation this association is affected and PABP (Montrer EBP Anticorps) is acted upon by PDI (Montrer PDIA3 Anticorps) resulting in stimulation of insulin translation.
Data (including data from studies using knockout mice) suggest that Ins1 and Ins2 are required for pancreatic beta-cell maturation; thus, Ins1 and Ins2 are needed for normal beta-cell development and for maintenance of normal beta-cell function.
cTAGE5 (Montrer CTAGE5 Montrer) deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin (Montrer Actbeta Anticorps) activity, rather than hormonal dysregulation.
report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2 (Montrer SOX2 Anticorps)) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification
Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
These findings suggest that GHRL (Montrer GHRL Anticorps) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (Montrer GHSR Anticorps) in the central nervous system and partly involved in carbohydrate-glycogen (Montrer GYS2 Anticorps) metabolism.
Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.