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anti-Human Insulin Anticorps:
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Buffalo (Bubalus) Polyclonal Insulin Primary Antibody pour IEM, ICC - ABIN617877
Tay, Wong: Insulin-like immunoreactivity in the monkey spinal cord. dans Acta anatomica 1992
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Human Monoclonal Insulin Primary Antibody pour IHC (p) - ABIN3043651
Han, Qiu, Zhang, Kong, Wang, Wang, Li, Duan, Wang, Song, Wang: Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats. dans Experimental biology and medicine (Maywood, N.J.) 2009
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Cow (Bovine) Monoclonal Insulin Primary Antibody pour CyTOF, FACS - ABIN4900790
Cucak, Grunnet, Rosendahl: Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. dans Journal of leukocyte biology 2014
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Human Polyclonal Insulin Primary Antibody pour EIA, FACS - ABIN372838
Madsen, Knauf, Gotfredsen, Pilling, Sjögren, Andersen, Andersen, de Boer, Manova, Barlas, Vundavalli, Nyborg, Knudsen, Moelck, Fagin: GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation. dans Endocrinology 2012
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Cow (Bovine) Monoclonal Insulin Primary Antibody pour FACS - ABIN4898619
Kalis, Bolmeson, Esguerra, Gupta, Edlund, Tormo-Badia, Speidel, Holmberg, Mayans, Khoo, Wendt, Eliasson, Cilio: Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. dans PLoS ONE 2012
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Human Monoclonal Insulin Primary Antibody pour ELISA (Capture), ELISA - ABIN617624
Back, Scheuner, Han, Song, Ribick, Wang, Gildersleeve, Pennathur, Kaufman: Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. dans Cell metabolism 2009
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Human Monoclonal Insulin Primary Antibody pour ELISA (Capture), ELISA - ABIN617623
Kojima, Fujimiya, Matsumura, Nakahara, Hara, Chan: Extrapancreatic insulin-producing cells in multiple organs in diabetes. dans Proceedings of the National Academy of Sciences of the United States of America 2004
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These data implicate the existence of beta cells enriched for inefficient insulin/C-peptide production in type 1 diabetes patients, potentially less susceptible to autoimmune destruction.
Serum C-peptide levels were strongly associated with increased serum TG and reduced HDL (Montrer HSD11B1 Anticorps)-C levels in the elderly.Our results suggest that serum C-peptide increases the risk of CVD via a pathway that increases TG or decreases HDL (Montrer HSD11B1 Anticorps)-C levels.
Proinsulin is involved in regulating the growth and differentiation of hematopoietic stem cells.
This article reviews the roles of CFTR (Montrer CFTR Anticorps) in epithelial cells, its regulatory role in insulin secretion, and a mechanism of CFTR (Montrer CFTR Anticorps) regulation by insulin. [review]
During HCV infection, adiponectin affects insulin sensitivity through triglycerides and after viral clearance, adiponectin levels were directly associated with insulin sensitivity and decreased upon improved hepatic fibrosis.
Data suggest that, in type 2 diabetes, the reduction in insulin secretion by pancreatic beta-cells can be considered, at least in part, to result from an imbalance of beta-cell renewal and apoptosis. [REVIEW]
the severity of metabolic syndrome exhibits long-term links to levels of insulin and adiponectin, suggesting potential genetic and environmental influences on insulin resistance over time
Data suggest that secretion of insulin by beta-cells is related to insulin resistance in complex manner; insulin secretion is associated with type 2 diabetes in obese and non-obese subjects, but insulin resistance is associated with type 2 diabetes only in non-obese subjects. Chinese subjects were used in these studies.
Results suggest that optimised lentiviral transduction of the insulin gene into primary canine mesenchymal stromal cells (cMSCs) renders these cells capable of secreting insulin over both the short- and long-term, in sufficient quantities in vitro to support their potential use in insulin gene therapy.
C-peptide-based measurements of insulin secretion are appropriate for assessing beta-cell function in SGLT2 (Montrer SLC5A2 Anticorps) inhibitor canagliflozin-treated participants.
Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (Montrer ATP1A1 Anticorps) activity and SFK signaling.
PTPLAD1 (Montrer PTPLAD1 Anticorps) and AMPK (Montrer PRKAA1 Anticorps) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (Montrer ATIC Anticorps) later accumulates in the Golgi/endosome fraction.
Pdx-1 (Montrer PDX1 Anticorps), MafA (Montrer MAFA Anticorps) and NeuroD1 (Montrer NEUROD1 Anticorps) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.
The interplay of the adiponectin system, TNFalpha (Montrer TNF Anticorps) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (Montrer PPARG Anticorps), as well as on the activation of main insulin signaling pathways, is reported.
Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.
Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.
Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.
The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (Montrer IGF1 Anticorps) levels are less easily modified.
insulin increased GCLc (Montrer GCLC Anticorps) promoter activity, which required a prerequisite increase or decrease in medium glucose
Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period
Differences between human and bovine insulin kinetics under shear
increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (Montrer LEP Anticorps)-NPY (Montrer NPY Anticorps) and insulin signaling pathways.
Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.
Contains Binding kinetics for insulin binding
Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (Montrer VMP1 Anticorps)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.
The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (Montrer FRAP1 Anticorps) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.
In-situ spectroscopic investigation of ultrasonic assisted unfolding and aggregation of insulin.
insulin supports early initiation of the mesodermal factor Brachyury (Montrer TBX1 Anticorps) and the signalling molecules Wnt3a (Montrer WNT3A Anticorps) and Wnt4 (Montrer WNT4 Anticorps) as well as the progression of mesoderm formation
Data show that type 1 diabetic blastocyst did not express insulin mRNA.
Data (including data from studies using knockout mice) suggest that Ins1 and Ins2 are required for pancreatic beta-cell maturation; thus, Ins1 and Ins2 are needed for normal beta-cell development and for maintenance of normal beta-cell function.
cTAGE5 (Montrer CTAGE5 Anticorps) deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin (Montrer Actbeta Anticorps) activity, rather than hormonal dysregulation.
report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2 (Montrer SOX2 Anticorps)) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification
Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
Data suggest that resveratrol acts on differentiating preadipocytes by inhibiting insulin signaling, mitochondrial biogenesis, and lipogenesis.
have characterized the distinctive sex-specific phenotypes exhibited by the ApoE(-/-):Ins2(+/Akita) mouse model and present evidence for the action of sex hormones on pancreatic beta-cell function
Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.
Mouse Ins2 and Ins1 promoters were transiently activated in mouse fetal hepatocytes of embryonic days 13.5 and 16.5, respectively.
Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
These findings suggest that GHRL (Montrer GHRL Anticorps) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (Montrer GHSR Anticorps) in the central nervous system and partly involved in carbohydrate-glycogen (Montrer GYS2 Anticorps) metabolism.
Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.