anti-Hamster Insulin anticorps pour Immunohistochemistry (Frozen Sections)

Recommended Insulin Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Insulin (INS) Anticorps
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Reactivité
Hamster, Humain, Porc, Rat (Rattus)
876
391
263
258
206
120
49
6
6
6
5
4
4
2
2
1
1
1
1
1
1
Hôte
Cobaye
709
179
52
16
3
1
Clonalité
Polyclonal
Conjugué
Cet anticorp Insulin est non-conjugé
47
38
37
23
22
22
22
17
17
14
14
14
14
14
14
14
14
10
9
8
8
8
5
5
5
5
5
5
2
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
507
352
229
205
189
181
146
124
66
64
33
26
15
11
8
6
5
4
4
3
3
2
2
1
1
1
1
1
Fournisseur
Connectez-vous pour afficher
Supplier Product No.
Connectez-vous pour afficher
Request

Recevoir ce produit gratuitement

Envoyez-nous votre proposition de validation. J'aimerais valider ce produit

Savoir plus

N° du produit ABIN115757
$ 830.50
Plus shipping costs $45.00

General

Antigène Insulin (INS) Anticorps
Reactivité Hamster, Humain, Porc, Rat (Rattus)
(876), (391), (263), (258), (206), (120), (49), (6), (6), (6), (5), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Hôte Cobaye
(709), (179), (52), (16), (3), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp Insulin est non-conjugé
(47), (38), (37), (23), (22), (22), (22), (17), (17), (14), (14), (14), (14), (14), (14), (14), (14), (10), (9), (8), (8), (8), (5), (5), (5), (5), (5), (5), (2), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(507), (352), (229), (205), (189), (181), (146), (124), (66), (64), (33), (26), (15), (11), (8), (6), (5), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Pubmed 4 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-Insulin anticorps

Détail du antigène Insulin Information d'application Stockage References for anti-Insulin antibody (ABIN115757) Images
Specificité The antibody recognizes Insulin produced by the B-cells of the pancreatic islets and by insulin-producing islet cell tumors. Absorption with 10-100 μg proinsulin per ml diluted antiserum inactivates the antiserum, while C-peptide and Insulin only partly reduce staining.
Réactivité croisée (Details) Also reacts to: Proinsulin
Purification Serum
Immunogène Synthetic Human proinsulin

Détail du antigène Insulin

Détail du produit anti-Insulin anticorps Information d'application Stockage References for anti-Insulin antibody (ABIN115757) Images Haut de la page
Antigène
Autre désignation Insulin (INS Antibody Extrait)
Sujet Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.Synonyms: INS
ID gène 3630
NCBI Accession NP_000198
UniProt P01308
Pathways Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation

Information d'application

Détail du produit anti-Insulin anticorps Détail du antigène Insulin Stockage References for anti-Insulin antibody (ABIN115757) Images Haut de la page
Indications d'application Immunofluorescence: 1: 1000 - 1: 2000, overnight incubation at 2-8C. Immunohistochemistry on frozen and paraffin sections: 1: 3000 - 1: 5000. Positive Control: Formalin-fixed paraffin sections of human pancreas
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Stockage

Détail du produit anti-Insulin anticorps Détail du antigène Insulin Information d'application References for anti-Insulin antibody (ABIN115757) Images Haut de la page
Format Liquid
Reconstitution Dissolve the antiserum in 50-100 μL distilled water, and dilute further in 0.1 M PBS with 1 % BSA and 0.09 % Sodium Azide
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody (in aliquots) at -20 °C.

References for anti-Insulin antibody (ABIN115757)

Détail du produit anti-Insulin anticorps Détail du antigène Insulin Information d'application Stockage Images Haut de la page
Background publications

Kohnert, Axcrona, Hehmke, Klöting, Sundler, Ahrén: "Islet neuronal abnormalities associated with impaired insulin secretion in type 2 diabetes in the Chinese hamster." dans: Regulatory peptides, Vol. 82, Issue 1-3, pp. 71-9, 1999

Ahrén, Gudbjartsson, Al-Amin, Mårtensson, Myrsén-Axcrona, Karlsson, Mulder, Sundler: "Islet perturbations in rats fed a high-fat diet." dans: Pancreas, Vol. 18, Issue 1, pp. 75-83, 1999

Myrsén-Axcrona, Karlsson, Sundler, Ahrén: "Dexamethasone induces neuropeptide Y (NPY) expression and impairs insulin release in the insulin-producing cell line RINm5F. Release of NPY and insulin through different pathways." dans: The Journal of biological chemistry, Vol. 272, Issue 16, pp. 10790-6, 1997

Myrsén, Ahrén, Sundler: "Dexamethasone-induced neuropeptide Y expression in rat islet endocrine cells. Rapid reversibility and partial prevention by insulin." dans: Diabetes, Vol. 45, Issue 10, pp. 1306-16, 1996