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anti-Human NEDD4 Anticorps:
anti-Mouse (Murine) NEDD4 Anticorps:
anti-Rat (Rattus) NEDD4 Anticorps:
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Human Polyclonal NEDD4 Primary Antibody pour IHC (p), WB - ABIN4338483
Zhang, Li, Rezaeian, Xu, Chou, Jin, Han, Pan, Wang, Long, Zhang, Huang, Tsai, Tsai, Logothetis, Lin: H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. dans Nature communications 2017
We further investigated whether curcumin exerts its antitumor activities via suppressing NEDD4 expression. We found that curcumin reduced the expression of NEDD4 and Notch1 and pAKT, leading to glioma cell growth inhibition, apoptosis, and suppression of migration and invasion. Moreover, deletion of NEDD4 expression enhanced the sensitivity of glioma cells to curcumin treatment
an oncogenic E3 ubiquitin ligase (Montrer MUL1 Anticorps) promotes loss of gap junctions and Cx43 (Montrer GJA1 Anticorps) degradation in human carcinoma cells.
NEDD4 exerts its oncogenic function partly due to regulation of PTEN and Notch-1 (Montrer NOTCH1 Anticorps) in bladder cancer cells.
In the present study, we identified that the adaptor protein Numb (Montrer NUMB Anticorps), which is demonstrated to be a novel binding partner of NEDD4-1, plays important roles in controlling PTEN ubiquitination through regulating NEDD4-1 activity and the association between PTEN and NEDD4-1.
NEDD4 is an autophagic E3 ubiquitin ligase (Montrer MUL1 Anticorps) that ubiquitylates SQSTM1 (Montrer SQSTM1 Anticorps), facilitating SQSTM1 (Montrer SQSTM1 Anticorps)-mediated inclusion body autophagy.
NEDD4 is largely involved in epithelial-mesenchymal transition features and chemoresistance of nasopharyngeal carcinoma cancer cells.
NEDD4 ligase regulates RTP801 (Montrer DDIT4 Anticorps) and is sensitive to Parkinson disease-associated oxidative stress
Two additional regulators of BST2 constitutive ubiquitylation and sorting to the lysosomes: the E3 ubiquitin ligases NEDD4 and MARCH8, are reported.
SQSTM1 is ubiquitinated by NEDD4 while LC3 functions as an activator of NEDD4 ligase activity.
Our results reveal a novel mechanism of upregulation of NEDD4 expression in pancreatic adenocarcinoma
these findings support NEDD4 as a novel regulator of adipogenesis by modulating the stability of PPARgamma (Montrer PPARG Anticorps).
expression or dysfunction of Nedd4 E3 ligase could be involved in vascular calcification of VSMCs by activating bone-forming signals during atherosclerosis progression
Nedd4-1 is required for efficient internalization of major growth factor receptors involved in liver regeneration and their downstream mitogenic signaling.
NPM1 (Montrer GJA1 Anticorps)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (Montrer CASP2 Anticorps) activation cascade.
these results suggest that Nedd4 suppresses colonic WNT (Montrer WNT2 Anticorps) signaling and tumor growth, at least in part, by suppressing the transcription factors LEF1 (Montrer LEF1 Anticorps) and YY1 (Montrer YY1 Anticorps).
Findings indicate that reducing Nedd4 protein by 50% significantly impairs long-term potentiation and long-term memory thereby demonstrating an important role for Nedd4 in these processes.
Upregulation of long non-coding RNA PAPAS (Montrer PSTPIP1 Anticorps) in response to hypoosmotic stress does not increase H4K20me3 because of Nedd4-dependent ubiquitinylation and proteasomal degradation of Suv4-20h2 (Montrer SUV420H2 Anticorps).
we propose that Nedd4 functions as a novel Pax7 (Montrer PAX7 Anticorps) regulator, which activity is temporally and spatially controlled to modulate the Pax7 (Montrer PAX7 Anticorps) protein levels and therefore satellite cell fate.
PDLIM7 (Montrer PDLIM7 Anticorps) is a bona fide skeletal muscle substrate of Nedd4-1.
show that absence of Nedd4 in pre-osteoblasts results in decreased cell proliferation and altered osteogenic differentiation
miR-1-mediated regulation of Nedd4/Nedd4L (Montrer NEDD4L Anticorps) expression may serve to broadly modulate the trafficking or degradation of Nedd4/Nedd4L (Montrer NEDD4L Anticorps) substrates in the heart
Nedd4Lo destabilizes Amph (Montrer AMPH Anticorps) in muscles, leading to impaired T-tubule formation and muscle function.
NEDD4 controls the Hippo pathway leading to coordinated cell proliferation and apoptosis
data in two evolutionarily distant model organisms strongly suggest that Nedd4 is a modifier of alpha-synuclein pathobiology and thus a potential target for neuroprotective therapies
Nedd4, another E3 ubiquitin ligase that may have a role in PD, is functionally related to Sep4 and could be involved in regulating Sep4 subcellular localization/trafficking.
splice isoforms of the same dNedd4 gene can lead to opposite effects on neuromuscular synaptogenesis
Nedd4 regulates endocytosis of notch (Montrer NOTCH1 Anticorps) and suppresses its ligand-independent activation.
These studies provide insights into the specific regulation of dNedd4-mediated ubiquitination of Comm and subsequent internalization of Comm or the Comm/Roundabout (Montrer ROBO1 Anticorps) complex, critical for CNS and muscle development.
dNedd4 and ubiquitination are required for Commissureless endocytosis and proper neuromuscular synaptogenesis.
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).
E3 ubiquitin-protein ligase NEDD4
, cell proliferation-inducing gene 53 protein
, neural precursor cell expressed developmentally down-regulated protein 4
, receptor-potentiating factor 1
, neural precursor cell expressed, developmentally down-regulated gene 4
, neural precursor cell expressed, developmentally down-regulated gene 4a
, neural precursor cell expressed, developmentally down-regulted gene 4
, neural precursor cell expressed, developmentally down-regulated 4
, ubiquitin-protein ligase Nedd4
, E3 ubiquitin-protein ligase NEDD4-like
, e3 ubiquitin-protein ligase NEDD4-like
, neural precursor cell expressed, developmentally down-regulated gene 4A